Selected Recent Publications of CADA members:
Zinc supplementation partially prevents renal pathological changes in diabetic rats.
Tang Y, Yang Q, Lu J, Zhang X, Suen D, Tan Y, Jin L, Xiao J, Xie R, Rane M, Li X, Cai L.
J Nutr Biochem. 2009 Apr 13. [Epub ahead of print]
Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications.
Liu Q, Sun L, Tan Y, Wang G, Lin X, Cai L.
Curr Med Chem. 2009;16(1):113-29. Review.
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.
Zhou G, Li X, Hein DW, Xiang X, Marshall JP, Prabhu SD, Cai L.
J Am Coll Cardiol. 2008 Aug 19;52(8):655-66.
Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications.
Cai L.
Curr Med Chem. 2007;14(20):2193-203. Review.
Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic {beta}-cells.
Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS.
Proc Natl Acad Sci U S A. 2009 Apr 20. [Epub ahead of print]
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.
Wu D, Pang Y, Ke Y, Yu J, He Z, Tautz L, Mustelin T, Ding S, Huang Z, Feng GS.
PLoS ONE. 2009;4(3):e4914. Epub 2009 Mar 17.
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS.
Mol Cell Biol. 2009 Jan;29(2):378-88. Epub 2008 Nov 10.
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase.
Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S.
Am J Pathol. 2008 May;172(5):1312-24. Epub 2008 Apr 10.
Reducing Grb2 Expression Mediates the Insulin Sensitizing Effect of Calorie Restriction.
Liu X, Liu M, Zhang JJ, Bai X, Ramos FJ, Van Remmen H, Richardson A, Liu FY, Dong LQ, Liu F.
Am J Physiol Endocrinol Metab. 2009 Feb 24. [Epub ahead of print]
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Wang C, Liu M, Riojas RA, Xin X, Gao Z, Zeng R, Wu J, Dong LQ, Liu F.
J Biol Chem. 2009 Jan 23;284(4):2038-44. Epub 2008 Dec 1.
A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization.
Liu M, Zhou L, Xu A, Lam KS, Wetzel MD, Xiang R, Zhang J, Xin X, Dong LQ, Liu F.
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18302-7. Epub 2008 Nov 14.
Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism.
Qiao L, Zou C, van der Westhuyzen DR , Shao J.
Diabetes. 2008 Jul;57(7):1824-33. Epub 2008 Mar 28.
Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.
Xie Z, Zhang J, Wu J, Viollet B, Zou MH.
Diabetes. 2008 Dec;57(12):3222-30. Epub 2008 Oct 3.
Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells.
Zhang J, Xie Z, Dong Y, Wang S, Liu C, Zou MH.
J Biol Chem. 2008 Oct 10;283(41):27452-61. Epub 2008 Aug 7.
Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo.
Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH.
J Biol Chem. 2008 Jul 18;283(29):20186-97. Epub 2008 May 12.
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.
Xie Z, Dong Y, Scholz R, Neumann D, Zou MH.
Circulation. 2008 Feb 19;117(7):952-62. Epub 2008 Feb 4.
Ye J, Gao Z, Yin J, He H: Hypoxia is a potential risk factor for
chronic inflammation and adiponectin reduction in adipose tissue of
ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab
293:E1118‑E1128, 2007
Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J: Macrophage Infiltration
into Adipose Tissue May Promote Angiogenesis for Adipose Tissue
Remodeling in Obesity. Am J Physiol Endocrinol Metab 295:E313‑E322, 2008
Yin J, Gao Z, He Q, Ye J: Role of hypoxia in obesity‑induced
disorders of glucose and lipid metabolism in adipose tissue. Am J
Physiol Endocrinol Metab doi:10.1152/ajpendo.90760.2008
Ye J: Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin
Resistance. Int J Obes DOI: Dec. 9th 2007, 2008
Xiaoqing Zhang, Guo Zhang, Hai Zhang, Michael Karin, Hua Bai, Dongsheng Cai.
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity.
Cell 135(1) pp. 61 - 73
Liangyou Rui
A link between protein translation and body weight
J. Clin. Invest. 2007 117: 310-313.
Decheng Ren, Yingjiang Zhou, David Morris, Minghua Li, Zhiqin Li, and Liangyou Rui
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
J. Clin. Invest. 2007 117: 397-406.
Nguyen TV, Ke Y, Zhang EE, Feng GS.
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
J Immunol. 2006 Nov 1;177(9):5990-6.
Chan RJ, Feng GS.
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Blood. 2006 Oct 19.
Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS.
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.
J Biol Chem. 2006 Nov 10;281(45):34374-80.
Dong XP, Li XM, Gao TM, Zhang EE, Feng GS, Xiong WC, Mei L.
Shp2 is dispensable in the formation and maintenance of the neuromuscular junction.
Neurosignals. 2006-2007;15(2):53-63. Epub 2006 Jul 11.
Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS.
Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.
Mol Cell Biol. 2006 Jun;26(12):4664-74.
Gao Z, He Q, Peng B, Chiao P and Ye J
Regulation of Nuclear Translocation of HDAC3 by IkBalpha Involves in TNF-inhibition of PPARgamma Function.
J. Biol. Chem. 281:4540-4547, 2006.
Riojas, R.A., Kikani, C.K., Wang, C., Mao, X., Zhou, L., Langlais, P.R., Hu, D., Roberts, J.L., Dong, L.Q., Liu, F. (2006)
Fine-tuning PDK1 activity by phosphorylation at Ser163.
J. Biol. Chem. 281 (in press).
Mao, X., Langlais, P., Riojas, R.J., Wang, L., Ramos, F.J., Fang, Q., Christ-Roberts, C., Hong, J., Kim, R.Y., Kikani, C.K., Liu, F., Dong, L.Q. (2006) APPL1 binds to adiponectin receptors and mediates adiponectin signaling and function.
Nat. Cell. Biol. 8, 516-523.
Ramos, F.J., Langlais, P., Hu, D., Dong, L.Q., and Liu F. (2006)
Grb10-mediated degradation of the insulin receptor: A mechanism of negative regulation.
Am. J. Physiol. Endocrinol. Metab. E1262-1266.
Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol. 2006 May;8(5):516-23.
Lu Cai, Jianxun Wang, Yan Li, Xuihua Sun, Lipeng Wang, Zhanxiang Zhou, and Y. James Kang
Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy
Diabetes 54: 1829-1837.
Gen-Sheng Feng
Shp2 as a therapeutic target for leptin resistance and obesity (REVIEW)
Expert Opinion on Therapeutic Targets, February 2006, Vol. 10, No. 1, Pages 135-142.
Yi-Hao Yu and Henry N. Ginsberg
Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue (REVIEW)
Circ. Res., May 2005; 96: 1042 - 1052.
Karel Chalupsky and Hua Cai
Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
PNAS 2005 102: 9056-9061; published online before print as 10.1073/pnas.0409594102
Zhanguo Gao, Paul Chiao, Xia Zhang, Xiaohong Zhang, Mitchell A. Lazar, Edward Seto, Howard A. Young, and Jianping Ye
Coactivators and Corepressors of NF-
B in I
B
Gene PromoterJ. Biol. Chem., Jun 2005; 280: 21091 - 21098 ; doi:10.1074/jbc.M500754200
Zhanguo Gao, Qing He, Bailu Peng, Paul J. Chiao, and Jianping Ye
Regulation of Nuclear Translocation of HDAC3 by I
B
Is Required for Tumor Necrosis Factor Inhibition of
Peroxisome Proliferator-activated Receptor
FunctionJ. Biol. Chem., Feb 2006; 281: 4540 - 4547 ; doi:10.1074/jbc.M507784200