IRIG: Ceramide in insulin resistance in "Cell Metabolism"
03/15/2007 23:27
Although it is
generally accepted that FFA is a risk factor for
insulin resistance, it is quite controversial
about the signaling molecules for
FFA-induced insulin resistance. Ceramide and DAG are
two derivatives of FFA. It has
been confusing about which of the two
FFA derivatives is the "dominant player" in the
translation of FFA signal into insulin resistance.
Each molecule is supported by multiple published
studies of many labs. In the current issue of
"Cell Metabolism", a study using transgenic
and pharmacological approaches demonstrated that
ceramide is the "dominant player". Inhibition
of ceramide led to blocking of insulin
resistance in three models: glucocorticoid, FFA and
obesity. In these conditions, DAG level was not
changed by ceramide inhibition. See attache PDF file.
Regarding adiponectin receptor knockout mice, there are two additional studies published in "Diabetes" and Endocrinology" this month along with the one in "Nature Medicine". It seems that the metabolic phenotypes are not consistent among the three independent studies. Attached are the PDF files from Diabetes and Endocrinology. These two papers are recommended by Drs. Lu Cai at the University of Louisville, and Jianhua Shao at the University of Kentucky.
by Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Regarding adiponectin receptor knockout mice, there are two additional studies published in "Diabetes" and Endocrinology" this month along with the one in "Nature Medicine". It seems that the metabolic phenotypes are not consistent among the three independent studies. Attached are the PDF files from Diabetes and Endocrinology. These two papers are recommended by Drs. Lu Cai at the University of Louisville, and Jianhua Shao at the University of Kentucky.
by Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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