IRIG: Botanicals and Adipogenesis
11/28/2006 07:36
Botanical products are widely used in folk medicines
in the treatment of metabolic or endocrine
diseases. The National Center for Complementary and
Alternative Medicines (NCCAM/NIH) are
supporting research in botanicals.
Now, single botanical compound with known
chemical structure are attracting more attention in
the basic research of metabolic
syndrom. In this regard, we
highlighted a "Nature" paper about
Resveratrol (in variety of fruits, such as grape
skin) in insulin sensitization and longevity in the
last IRIG post. Here, two more examples published in
"Cell Metabolism" are included.
The first is Genipin that was reported to inhibit UCP-2 (uncoupling protein 2) in beta-cells, and protect beta-cell function in type 2 diabetes. The second is Chloroquine, a medicine for treatment of malaria. Chloroquine is reported to activate ATM (Ataxia Telangiectasia Mutated) kinase and reduce risk of cardivescular diseases in apoE-/- deficient mice (recommended by Dr. Frank Greenway at PBRC). Both Genipin and Chloroquine are single compounds from the Chinese Herbal Medicines. See attached PDF files.
Mechanisms of adipogenesis is of interest in basic research of obesity. In the current issue of "Nature Reviews Molecular Cell Biology", there is a review about adipogenesis, which should include new insights in the molecular network controlling adipogenesis. See attached PDF file (provided by Dr. Feng Liu at UTHSC, San Antonio).
by Jianping
—----------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
The first is Genipin that was reported to inhibit UCP-2 (uncoupling protein 2) in beta-cells, and protect beta-cell function in type 2 diabetes. The second is Chloroquine, a medicine for treatment of malaria. Chloroquine is reported to activate ATM (Ataxia Telangiectasia Mutated) kinase and reduce risk of cardivescular diseases in apoE-/- deficient mice (recommended by Dr. Frank Greenway at PBRC). Both Genipin and Chloroquine are single compounds from the Chinese Herbal Medicines. See attached PDF files.
Mechanisms of adipogenesis is of interest in basic research of obesity. In the current issue of "Nature Reviews Molecular Cell Biology", there is a review about adipogenesis, which should include new insights in the molecular network controlling adipogenesis. See attached PDF file (provided by Dr. Feng Liu at UTHSC, San Antonio).
by Jianping
—----------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
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