IRIG: Longevity in "Science" and Lipid-ER interaction in "Nature"
08/04/2007 14:54
Insulin resistance in
obesity increases risk for type 2 diabetes and
cardiovascular diseases. These diseases usually
accelerate aging and reduce lifespan. However, a
study in the current issue of Science suggests that
insulin resistance from IRS-2 knockout increased
lifespan together with body weight. The
abstract states that "In mice, less insulin
receptor substrate–2 (Irs2) signaling throughout the
body or just in the brain extended life span up to
18%." The study suggests that the role of insulin
resistance in aging and longevity of obese
subjects is not that simple. See attached paper that is
recommended by Dr. Dixit at
PBRC.
ER stress in obesity has been used to explain insulin resistance. Oversupply of lipid may cause ER stress. However, it is not clear how lipid induces ER stress in obese condition. In the current issue of Nature, an article presents a hypothesis for the regulation of ER function by lipid. See attached paper.
By Jianping at PBRC
------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
ER stress in obesity has been used to explain insulin resistance. Oversupply of lipid may cause ER stress. However, it is not clear how lipid induces ER stress in obese condition. In the current issue of Nature, an article presents a hypothesis for the regulation of ER function by lipid. See attached paper.
By Jianping at PBRC
------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
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