IRIG: NYP jumps out of brain, article in Nature Medicine
07/11/2007 02:19
Neuropeptide Y (NPY)
is a neurotransmitter with well-known function in the
stimulation of food intake in the brain. In
ob/ob mice, expression of NPY is increased
in the brain and this increase contributes
to hyperphagia, which leads to obesity
in ob/ob mice on a regular diet. It is generally
believed that NPY is expressed in the brain, and acts
locally in the brain. In the current issue of Nature
Medicine, a new study suggests that NPY is able to
act in the adipose tissue for development
of central obesity in stress condition, such as cold
or aggression. This peripheral activity of NPY
includes stimulation of proliferation and
differentiation of preadipocytes, promotion of
angiogenesis and inhibition of lipolysis in adipose
tissue. NYP is found to be released from
sympathetic nerves in response to the stress. The
study suggests a novel function
of NPY. Attached is the paper and
commentary.
This paper is also recommended by Drs. Eric Ravussin and Vishwa Dixit at PBRC.
By Jianping at PBRC
--------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
This paper is also recommended by Drs. Eric Ravussin and Vishwa Dixit at PBRC.
By Jianping at PBRC
--------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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