Oct 2006
IRIG: Insulin, PGC-1, GSK-3 in "Nature" and "Cell"
10/30/2006 07:16 Filed in: 2006
In the current "Nature Reviews: Molecular Cell
Biology", there is a nice review article about
signaling pathway of insulin. It introduces current
understanding of the pathway and also summarizes
major events in the history on study of
the pathway.
Attached is the PDF file
(provided by Feng Liu at UTHSCS).
In the current "Cell", a study demonstrates that PGC-1a is an important nuclear protein in the inhibition of reactive oxygen species (ROS). In the absence of PGC-1a, ROS production is increased from the respiratory chain reaction in the mitochondria. The ROS leads to degeration of neuron in cell culture and in PGC-1a KO mice. See attached PFD file.
In the current "Molecular Cell", a study suggests that mTOR/S6K is able to regulate GSK-3 activity through Akt. See attached PDF file.
In the current JCI, a study supports that free fatty acids induce inflammation in adipocytes and macrophages through activation of the Toll like receptor 4 (TLR4). In the TLR4 knockout female mice, inflammation was reduced and insulin sensitivity was preserved on high fat diet although the body weight was even higher. See attached PDF file.
By Jianping at PBRC
—-------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
In the current "Cell", a study demonstrates that PGC-1a is an important nuclear protein in the inhibition of reactive oxygen species (ROS). In the absence of PGC-1a, ROS production is increased from the respiratory chain reaction in the mitochondria. The ROS leads to degeration of neuron in cell culture and in PGC-1a KO mice. See attached PFD file.
In the current "Molecular Cell", a study suggests that mTOR/S6K is able to regulate GSK-3 activity through Akt. See attached PDF file.
In the current JCI, a study supports that free fatty acids induce inflammation in adipocytes and macrophages through activation of the Toll like receptor 4 (TLR4). In the TLR4 knockout female mice, inflammation was reduced and insulin sensitivity was preserved on high fat diet although the body weight was even higher. See attached PDF file.
By Jianping at PBRC
—-------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
|
IRIG: Papers in Nature about PGC-1 and Food intake
10/18/2006 21:18 Filed in: 2006
PGC-1 (PPARg coactivator 1) was identified as
a transcriptional coactivator for nuclear
receptor PPARg. Now, PGC-1 is known to interact with
many transcription factors in the regulation of gene
expression in addition to PPARg. The biological
activities of PGC-1 are well-established in the
promotion of hepatic gluconeogenesis and
mitochondrial biosynthesis. In the regulation of
gluconeogenesis in the liver, PGC-1 has
been shown to promote transcription of
the rate-limiting enzyme (G6Pase and
PEPCK) through an interaction
with transcription factors including HNF4, FOXO1
and CREB. In a recent issue of Nature, it
is reported that PGC-1 does not directly
interact with FOXO1 in G6Pase gene promoter, and is
not required for the FOXO1 function. The PGC-1/HNF4
interaction is confirmed for their function in
G6Pase expression. Attached is the PDF
file.
Regulation of food intake is a focus in obesity research with an expectation that the research will lead to identification of a target for drug intervention of food intake, which will be useful in prevention and treatment of obesity. However, the current understanding of the mechanism of food intake has not been able to provide an effective drug target for such a purpose. As a result, the research in this field has drawn a great deal of attention. This is reflected by the increasing number of review articles in the high profile journals in recent years. In Nature, a review about food intake is published recently (see attached PDF file). This paper is recommended by Dr. Roy Martin at Pennington.
By Jianping at PBRC
—---------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Regulation of food intake is a focus in obesity research with an expectation that the research will lead to identification of a target for drug intervention of food intake, which will be useful in prevention and treatment of obesity. However, the current understanding of the mechanism of food intake has not been able to provide an effective drug target for such a purpose. As a result, the research in this field has drawn a great deal of attention. This is reflected by the increasing number of review articles in the high profile journals in recent years. In Nature, a review about food intake is published recently (see attached PDF file). This paper is recommended by Dr. Roy Martin at Pennington.
By Jianping at PBRC
—---------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Interesting papers in JAMA and JBC
10/18/2006 07:35 Filed in: 2006
Following are some interesting papers in JAMA and
recent issues of JBC.
—-------------------------------------------------------------------------
Insulin Effects Weigh Heavy on the Brain M. J. Friedrich JAMA. 2006; 296:1717-1718. [Extract] [Full Text] [PDF]
Oncostatin M inhibits adipogenesis through the Ras/ERK and STAT5 signaling pathways Yuichiro Miyaoka, Minoru Tanaka, Takahiro Naiki, and Atsushi Miyajima published 6 October 2006, 10.1074/jbc.M606089200 [Abstract] [PDF]
Transcription Factor Activating Enhancer-binding Protein-2: A NEGATIVE REGULATOR OF ADIPONECTIN GENE EXPRESSION Kazuhiro Ikeda, Hiroshi Maegawa, Satoshi Ugi, Yukari Tao, Yoshihiko Nishio, Shuichi Tsukada, Shiro Maeda, and Atsunori Kashiwagi J. Biol. Chem. 2006; 281:31245-31253. [Abstract] [Full Text] [PDF]
Negative Modulation of RXR Transcriptional Activity by Small Ubiquitin-related Modifier (SUMO) Modification and Its Reversal by SUMO-specific Protease SUSP1 Soo Joon Choi, Sung Soo Chung, Eun Jung Rho, Hyung Woo Lee, Moon Hee Lee, Hueng-Sik Choi, Jae Hong Seol, Sung Hee Baek, Ok Sun Bang, and Chin Ha Chung J. Biol. Chem. 2006; 281:30669-30677. [Abstract] [Full Text] [PDF]
A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion Sarah M. Ronnebaum, Olga Ilkayeva, Shawn C. Burgess, Jamie W. Joseph, Danhong Lu, Robert D. Stevens, Thomas C. Becker, A. Dean Sherry, Christopher B. Newgard, and Mette V. Jensen J. Biol. Chem. 2006; 281:30593-30602. [Abstract] [Full Text] [PDF]
Underexpressed Coactivators PGC1 AND SRC1 Impair Hepatocyte Nuclear Factor 4 Function and Promote Dedifferentiation in Human Hepatoma Cells Celia P. Martínez-Jiménez, M. José Gómez-Lechón, José V. Castell, and Ramiro Jover J. Biol. Chem. 2006; 281:29840-29849. [Abstract] [Full Text] [PDF]
Effect of TRB3 on Insulin and Nutrient-stimulated Hepatic p70 S6 Kinase Activity Rie Matsushima, Nagakatsu Harada, Nicholas J. G. Webster, Yasuo M. Tsutsumi, and Yutaka Nakaya J. Biol. Chem. 2006; 281:29719-29729. [Abstract] [Full Text] [PDF]
Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-B Activation: TAO2 REGULATES TAK1 PATHWAYS Wei-Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto, and Jun Ninomiya-Tsuji J. Biol. Chem. 2006; 281:28802-28810. [Abstract] [Full Text] [PDF]
Insulin Regulation of Cholesterol 7-Hydroxylase Expression in Human Hepatocytes: ROLES OF FORKHEAD BOX O1 AND STEROL REGULATORY ELEMENT-BINDING PROTEIN 1c Tiangang Li, Xiaoying Kong, Erika Owsley, Ewa Ellis, Stephen Strom, and John Y. L. Chiang J. Biol. Chem. 2006; 281:28745-28754. [Abstract] [Full Text] [PDF]
Destruction of Pancreatic -Cells by Transgenic Induction of Prostaglandin E2 in the Islets Hiroko Oshima, Makoto Mark Taketo, and Masanobu Oshima J. Biol. Chem. 2006; 281:29330-29336. [Abstract] [Full Text] [PDF]
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion Jamie W. Joseph, Mette V. Jensen, Olga Ilkayeva, Ferdinando Palmieri, Cristina Alarcon, Christopher J. Rhodes, and Christopher B. Newgard published 25 September 2006, 10.1074/jbc.M602606200 [Abstract] [PDF]
by Jianping at PBRC
-----------------------------—-
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
—-------------------------------------------------------------------------
Insulin Effects Weigh Heavy on the Brain M. J. Friedrich JAMA. 2006; 296:1717-1718. [Extract] [Full Text] [PDF]
Oncostatin M inhibits adipogenesis through the Ras/ERK and STAT5 signaling pathways Yuichiro Miyaoka, Minoru Tanaka, Takahiro Naiki, and Atsushi Miyajima published 6 October 2006, 10.1074/jbc.M606089200 [Abstract] [PDF]
Transcription Factor Activating Enhancer-binding Protein-2: A NEGATIVE REGULATOR OF ADIPONECTIN GENE EXPRESSION Kazuhiro Ikeda, Hiroshi Maegawa, Satoshi Ugi, Yukari Tao, Yoshihiko Nishio, Shuichi Tsukada, Shiro Maeda, and Atsunori Kashiwagi J. Biol. Chem. 2006; 281:31245-31253. [Abstract] [Full Text] [PDF]
Negative Modulation of RXR Transcriptional Activity by Small Ubiquitin-related Modifier (SUMO) Modification and Its Reversal by SUMO-specific Protease SUSP1 Soo Joon Choi, Sung Soo Chung, Eun Jung Rho, Hyung Woo Lee, Moon Hee Lee, Hueng-Sik Choi, Jae Hong Seol, Sung Hee Baek, Ok Sun Bang, and Chin Ha Chung J. Biol. Chem. 2006; 281:30669-30677. [Abstract] [Full Text] [PDF]
A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion Sarah M. Ronnebaum, Olga Ilkayeva, Shawn C. Burgess, Jamie W. Joseph, Danhong Lu, Robert D. Stevens, Thomas C. Becker, A. Dean Sherry, Christopher B. Newgard, and Mette V. Jensen J. Biol. Chem. 2006; 281:30593-30602. [Abstract] [Full Text] [PDF]
Underexpressed Coactivators PGC1 AND SRC1 Impair Hepatocyte Nuclear Factor 4 Function and Promote Dedifferentiation in Human Hepatoma Cells Celia P. Martínez-Jiménez, M. José Gómez-Lechón, José V. Castell, and Ramiro Jover J. Biol. Chem. 2006; 281:29840-29849. [Abstract] [Full Text] [PDF]
Effect of TRB3 on Insulin and Nutrient-stimulated Hepatic p70 S6 Kinase Activity Rie Matsushima, Nagakatsu Harada, Nicholas J. G. Webster, Yasuo M. Tsutsumi, and Yutaka Nakaya J. Biol. Chem. 2006; 281:29719-29729. [Abstract] [Full Text] [PDF]
Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-B Activation: TAO2 REGULATES TAK1 PATHWAYS Wei-Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto, and Jun Ninomiya-Tsuji J. Biol. Chem. 2006; 281:28802-28810. [Abstract] [Full Text] [PDF]
Insulin Regulation of Cholesterol 7-Hydroxylase Expression in Human Hepatocytes: ROLES OF FORKHEAD BOX O1 AND STEROL REGULATORY ELEMENT-BINDING PROTEIN 1c Tiangang Li, Xiaoying Kong, Erika Owsley, Ewa Ellis, Stephen Strom, and John Y. L. Chiang J. Biol. Chem. 2006; 281:28745-28754. [Abstract] [Full Text] [PDF]
Destruction of Pancreatic -Cells by Transgenic Induction of Prostaglandin E2 in the Islets Hiroko Oshima, Makoto Mark Taketo, and Masanobu Oshima J. Biol. Chem. 2006; 281:29330-29336. [Abstract] [Full Text] [PDF]
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion Jamie W. Joseph, Mette V. Jensen, Olga Ilkayeva, Ferdinando Palmieri, Cristina Alarcon, Christopher J. Rhodes, and Christopher B. Newgard published 25 September 2006, 10.1074/jbc.M602606200 [Abstract] [PDF]
by Jianping at PBRC
-----------------------------—-
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Leptin action in "Neuron"
10/04/2006 07:46 Filed in: 2006
Following are some interesting papers in the current
issue of Neuron (Neuron, Vol. 51, Iss. 6, 2006).
Leptin in Energy Balance and Reward: Two Faces of the Same Coin?
Pages 678-680
Daniela Cota, Jason G. Barrera and Randy J. Seeley
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Pages 801-810
Jonathan D. Hommel, Richard Trinko, Robert M. Sears, Dan Georgescu, Zong-Wu Liu, Xiao-Bing Gao, Jeremy J. Thurmon, Michela Marinelli and Ralph J. DiLeone
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Pages 811-822
Stephanie Fulton, Pavlos Pissios, Ramon Pinol Manchon, Linsey Stiles, Lauren Frank, Emmanuel N. Pothos, Eleftheria Maratos-Flier and Jeffrey S. Flier
Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance
Pages 691-702
Alfonso Abizaid, Qian Gao and Tamas L. Horvath
By Jianping at PBRC/LSU
----------*-
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Leptin in Energy Balance and Reward: Two Faces of the Same Coin?
Pages 678-680
Daniela Cota, Jason G. Barrera and Randy J. Seeley
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Pages 801-810
Jonathan D. Hommel, Richard Trinko, Robert M. Sears, Dan Georgescu, Zong-Wu Liu, Xiao-Bing Gao, Jeremy J. Thurmon, Michela Marinelli and Ralph J. DiLeone
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Pages 811-822
Stephanie Fulton, Pavlos Pissios, Ramon Pinol Manchon, Linsey Stiles, Lauren Frank, Emmanuel N. Pothos, Eleftheria Maratos-Flier and Jeffrey S. Flier
Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance
Pages 691-702
Alfonso Abizaid, Qian Gao and Tamas L. Horvath
By Jianping at PBRC/LSU
----------*-
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Gluconeogenesis and insulin receptor in "Nature"
10/04/2006 07:45 Filed in: 2006
Hepatic gluconeogenesis is critical to glucose
homeostasis. It contributes to hyperglycemia in type
2 diabetes when the function is too strong. It causes
hypoglycemia in fasting condition if the function is
too weak. Regulation of hepatic gluconeogenesis is an
hot area and many transcription factors and cofactors
have been identified in the mechanism study, such as
FOXO1, GR, CREB, HNF4, PGC-1, and SIRT1. In the
current issue of Nature Medicine, a new study
suggests that ligand-independent nuclear receptors
(Nur77, Nurr1 and NOR1) are involved in hepatic
gluconeogenesis in the response to glucogan-cAMP
pathway. Expression of these receptors are induced by
cAMP-CREB axis. Attached is the PDF file of the
paper.
Insulin receptor contains two alpha subunits and two beta subunits. The alpha subunits bind to insulin and the beta units catalyze tyrosine phosphorylation of itself and the IRS proteins. It was not clear how the receptor forms the binding site for insulin. In the current issue of Nature, this question is addressed by a study using protein crystal structure. See attached paper.
Gluconeogenesis and NR4A
Structure of insulin receptor
by Jianping at PBRC/LSU
*---------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Insulin receptor contains two alpha subunits and two beta subunits. The alpha subunits bind to insulin and the beta units catalyze tyrosine phosphorylation of itself and the IRS proteins. It was not clear how the receptor forms the binding site for insulin. In the current issue of Nature, this question is addressed by a study using protein crystal structure. See attached paper.
Gluconeogenesis and NR4A
Structure of insulin receptor
by Jianping at PBRC/LSU
*---------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: JBC papers
10/04/2006 07:45 Filed in: 2006
Overexpression of Monocyte Chemoattractant Protein-1
in Adipose Tissues Causes Macrophage Recruitment and
Insulin Resistance
Nozomu Kamei, Kazuyuki Tobe, Ryo Suzuki, Mitsuru Ohsugi, Taku Watanabe, Naoto Kubota, Norie Ohtsuka-Kowatari, Katsuyoshi Kumagai, Kentaro Sakamoto, Masatoshi Kobayashi, Toshimasa Yamauchi, Kohjiro Ueki, Yumiko Oishi, Satoshi Nishimura, Ichiro Manabe, Haruo Hashimoto, Yasuyuki Ohnishi, Hitomi Ogata, Kumpei Tokuyama, Masaki Tsunoda, Tomohiro Ide, Koji Murakami, Ryozo Nagai, and Takashi Kadowaki
J. Biol. Chem. 2006; 281:26602-26614. [Abstract] [Full Text] [PDF]
ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor (PPAR) stimulation
Chang-Hoon Woo, Michael P. Massett, Tetsuro Shishido, Seigo Itoh, Bo Ding, Carolyn McClain, Wenyi Che, Sreesatya Raju Vulapalli, Chen Yan, and Jun-ichi Abe
published 30 August 2006, 10.1074/jbc.M602369200 [Abstract] [PDF]
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle
Henning F. Kramer, Carol A. Witczak, Eric B. Taylor, Nobuharu Fujii, Michael F. Hirshman, and Laurie J. Goodyear
published 25 August 2006, 10.1074/jbc.M605461200 [Abstract] [PDF]
5-Aminoimidazole-4-carboxamide-1--D-ribofuranoside-induced AMP-activated Protein Kinase Phosphorylation Inhibits Basal and Insulin-stimulated Glucose Uptake, Lipid Synthesis, and Fatty Acid Oxidation in Isolated Rat Adipocytes
Mandeep Pinky Gaidhu, Sergiu Fediuc, and Rolando Bacis Ceddia
J. Biol. Chem. 2006; 281:25956-25964. [Abstract] [Full Text] [PDF]
Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting, cAMP, Hepatocyte Nuclear Factor , and the Coactivator Peroxisome Proliferator-activated Receptor Coactivator-1
Xunshan Ding, Kristin Lichti, Insook Kim, Frank J. Gonzalez, and Jeff L. Staudinger
J. Biol. Chem. 2006; 281:26540-26551. [Abstract] [Full Text] [PDF]
AKT2 regulates cardiac metabolism and cardiomyocyte survival
Brian J. DeBosch, Nandakumar Sambandam, Carla S. Weinheimer, Michael Courtois, and Anthony J. Muslin
published 31 August 2006, 10.1074/jbc.M513087200 [Abstract]
By Jianping at PBRC
—-------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Nozomu Kamei, Kazuyuki Tobe, Ryo Suzuki, Mitsuru Ohsugi, Taku Watanabe, Naoto Kubota, Norie Ohtsuka-Kowatari, Katsuyoshi Kumagai, Kentaro Sakamoto, Masatoshi Kobayashi, Toshimasa Yamauchi, Kohjiro Ueki, Yumiko Oishi, Satoshi Nishimura, Ichiro Manabe, Haruo Hashimoto, Yasuyuki Ohnishi, Hitomi Ogata, Kumpei Tokuyama, Masaki Tsunoda, Tomohiro Ide, Koji Murakami, Ryozo Nagai, and Takashi Kadowaki
J. Biol. Chem. 2006; 281:26602-26614. [Abstract] [Full Text] [PDF]
ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor (PPAR) stimulation
Chang-Hoon Woo, Michael P. Massett, Tetsuro Shishido, Seigo Itoh, Bo Ding, Carolyn McClain, Wenyi Che, Sreesatya Raju Vulapalli, Chen Yan, and Jun-ichi Abe
published 30 August 2006, 10.1074/jbc.M602369200 [Abstract] [PDF]
AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle
Henning F. Kramer, Carol A. Witczak, Eric B. Taylor, Nobuharu Fujii, Michael F. Hirshman, and Laurie J. Goodyear
published 25 August 2006, 10.1074/jbc.M605461200 [Abstract] [PDF]
5-Aminoimidazole-4-carboxamide-1--D-ribofuranoside-induced AMP-activated Protein Kinase Phosphorylation Inhibits Basal and Insulin-stimulated Glucose Uptake, Lipid Synthesis, and Fatty Acid Oxidation in Isolated Rat Adipocytes
Mandeep Pinky Gaidhu, Sergiu Fediuc, and Rolando Bacis Ceddia
J. Biol. Chem. 2006; 281:25956-25964. [Abstract] [Full Text] [PDF]
Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting, cAMP, Hepatocyte Nuclear Factor , and the Coactivator Peroxisome Proliferator-activated Receptor Coactivator-1
Xunshan Ding, Kristin Lichti, Insook Kim, Frank J. Gonzalez, and Jeff L. Staudinger
J. Biol. Chem. 2006; 281:26540-26551. [Abstract] [Full Text] [PDF]
AKT2 regulates cardiac metabolism and cardiomyocyte survival
Brian J. DeBosch, Nandakumar Sambandam, Carla S. Weinheimer, Michael Courtois, and Anthony J. Muslin
published 31 August 2006, 10.1074/jbc.M513087200 [Abstract]
By Jianping at PBRC
—-------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Improve insulin sensitivity by ER stress inhibitors(Science paper)
10/04/2006 07:44 Filed in: 2006
Inhibition of IRS-1 function by serine
phosphorylation represents a mechanism of
post-receptor insulin resistance. It is well known
that activation of serine kinase JNK (JUN N-terminal
Kinase) leads to insulin resistance through this
mechanism. In study of obese-related JNK activation,
ER stress was found to be a risk factor for JNK
activation in obese mice. The study was published in
Science in 2004. If this hypothesis is right,
chemical inhibitors for ER stress should be able to
improve insulin sensitivity in obese mice. This
possibility receives support from a new study
published in the current issue of Science. This new
study is from the same research group. Instead of
adipose tissue in the earlier study, the liver is the
focus in this new study for improvement of insulin
sensitivity by the ER stress inhibitors. Attached are
the PDF files of both studies.
ER stress in IR in 2004
ER stress inhibitor in 2006
By Jianping at PBRC
*---------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
ER stress in IR in 2004
ER stress inhibitor in 2006
By Jianping at PBRC
*---------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Papers in JBC
10/04/2006 07:43 Filed in: 2006
RIP140 expression is stimulated by ERR during
adipogenesis
Donna Nichol, Mark Christian, Jennifer H. Steel, Roger White, and Malcolm G. Parker
published 21 August 2006, 10.1074/jbc.M604803200 [Abstract] [PDF]
Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes
Hua-Jun He, Tie-Nian Zhu, Yi Xie, Jinshui Fan, Sutapa Kole, Satya Saxena, and Michel Bernier
published 22 August 2006, 10.1074/jbc.M603762200 [Abstract] [PDF]
The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids
David J. Durgan, Nowice A. Trexler, Oluwaseun Egbejimi, Tracy A. McElfresh, Hee Yun Suk, Lauren E. Petterson, Chad A. Shaw, Paul E. Hardin, Molly S. Bray, Margaret P. Chandler, Chi-Wing Chow, and Martin E. Young
J. Biol. Chem. 2006; 281:24254-24269. [Abstract] [Full Text] [PDF]
The Role of Src Kinase in Insulin-like Growth Factor-dependent Mitogenic Signaling in Vascular Smooth Muscle Cells
Jaroslava Lieskovska, Yan Ling, Jane Badley-Clarke, and David R. Clemmons
J. Biol. Chem. 2006; 281:25041-25053. [Abstract] [Full Text] [PDF]
Peroxisome Proliferator-activated Receptor Promotes Epithelial to Mesenchymal Transformation by Rho GTPase-dependent Activation of ERK1/2
Lu Chen, Brian M. Necela, Weidong Su, Masahiro Yanagisawa, Panos Z. Anastasiadis, Alan P. Fields, and E. Aubrey Thompson
J. Biol. Chem. 2006; 281:24575-24587. [Abstract] [Full Text] [PDF]
Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1
Lifu Wang, Christopher J. Rhodes, and John C. Lawrence, Jr.
J. Biol. Chem. 2006; 281:24293-24303. [Abstract] [Full Text] [PDF]
Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappa B activation, inducible nitric oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages
Xueyuan Zhou, Wenxiu Yang, and Junying Li
published 21 August 2006, 10.1074/jbc.M602739200 [Abstract] [PDF]
Toward the Active Conformation of Insulin: STEREOSPECIFIC MODULATION OF A STRUCTURAL SWITCH IN THE B CHAIN
Qing-xin Hua, Satoe Nakagawa, Shi-Quan Hu, Wenhua Jia, Shuhua Wang, and Michael A. Weiss
J. Biol. Chem. 2006; 281:24900-24909. [Abstract] [Full Text] [PDF]
----------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Donna Nichol, Mark Christian, Jennifer H. Steel, Roger White, and Malcolm G. Parker
published 21 August 2006, 10.1074/jbc.M604803200 [Abstract] [PDF]
Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes
Hua-Jun He, Tie-Nian Zhu, Yi Xie, Jinshui Fan, Sutapa Kole, Satya Saxena, and Michel Bernier
published 22 August 2006, 10.1074/jbc.M603762200 [Abstract] [PDF]
The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids
David J. Durgan, Nowice A. Trexler, Oluwaseun Egbejimi, Tracy A. McElfresh, Hee Yun Suk, Lauren E. Petterson, Chad A. Shaw, Paul E. Hardin, Molly S. Bray, Margaret P. Chandler, Chi-Wing Chow, and Martin E. Young
J. Biol. Chem. 2006; 281:24254-24269. [Abstract] [Full Text] [PDF]
The Role of Src Kinase in Insulin-like Growth Factor-dependent Mitogenic Signaling in Vascular Smooth Muscle Cells
Jaroslava Lieskovska, Yan Ling, Jane Badley-Clarke, and David R. Clemmons
J. Biol. Chem. 2006; 281:25041-25053. [Abstract] [Full Text] [PDF]
Peroxisome Proliferator-activated Receptor Promotes Epithelial to Mesenchymal Transformation by Rho GTPase-dependent Activation of ERK1/2
Lu Chen, Brian M. Necela, Weidong Su, Masahiro Yanagisawa, Panos Z. Anastasiadis, Alan P. Fields, and E. Aubrey Thompson
J. Biol. Chem. 2006; 281:24575-24587. [Abstract] [Full Text] [PDF]
Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1
Lifu Wang, Christopher J. Rhodes, and John C. Lawrence, Jr.
J. Biol. Chem. 2006; 281:24293-24303. [Abstract] [Full Text] [PDF]
Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappa B activation, inducible nitric oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages
Xueyuan Zhou, Wenxiu Yang, and Junying Li
published 21 August 2006, 10.1074/jbc.M602739200 [Abstract] [PDF]
Toward the Active Conformation of Insulin: STEREOSPECIFIC MODULATION OF A STRUCTURAL SWITCH IN THE B CHAIN
Qing-xin Hua, Satoe Nakagawa, Shi-Quan Hu, Wenhua Jia, Shuhua Wang, and Michael A. Weiss
J. Biol. Chem. 2006; 281:24900-24909. [Abstract] [Full Text] [PDF]
----------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Papers in JCI and JBC
10/04/2006 07:43 Filed in: 2006
Dual role of transcription factor FoxO1 in
controlling hepatic insulin sensitivity and lipid
metabolism
Michihiro Matsumoto, Seongah Han, Tadahiro Kitamura, and Domenico Accili
published 10 August 2006, 10.1172/JCI27047 [Abstract] [PDF]
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-B activation: TAO2 regulates TAK1 pathways
Wei-Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto, and Jun Ninomiya-Tsuji
published 7 August 2006, 10.1074/jbc.M603627200 [Abstract] [PDF]
Dual Regulation of Rho and Rac by p120 Catenin Controls Adipocyte Plasma Membrane Trafficking
June C. Hou, Satoshi Shigematsu, Howard C. Crawford, Panos Z. Anastasiadis, and Jeffrey E. Pessin
J. Biol. Chem. 2006; 281:23307-23312. [Abstract] [Full Text] [PDF]
Identification of novel glycogen synthase kinase-3 substrate interacting residues suggests a common mechanism for substrate recognition
Ronit Ilouz, Noga Kowalsman, Miriam Eisenstein, and Hagit Eldar-Finkelman
published 7 August 2006, 10.1074/jbc.M604633200 [Abstract] [PDF]
Under-expressed coactivators PGC1 and SRC1 impair HNF4 function and promote dedifferentiation in human hepatoma cells
Celia P. Martinez-Jimenez, Marin José Gomez-Lechon, Jose V. Castell, and Ramiro Jover
published 4 August 2006, 10.1074/jbc.M604046200 [Abstract] [PDF]
PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum
Stephen S. Lin, Michael C. Bassik, Heikyung Suh, Mari Nishino, Jason D. Arroyo, William C. Hahn, Stanley J. Korsmeyer, and Thomas M. Roberts
J. Biol. Chem. 2006; 281:23003-23012. [Abstract] [Full Text] [PDF]
Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet -cells. VOLUME 281 (2006) PAGES 15884-15892
Melissa K. Lingohr, Isabelle Briaud, Lorna M. Dickson, Jill F. McCuaig, Cristina Alarcón, Barton L. Wicksteed, and Christopher J. Rhodes
J. Biol. Chem. 2006; 281:23296-a. [Full Text] [PDF]
The Essential Role of the Death Domain Kinase Receptor-interacting Protein in Insulin Growth Factor-I-induced c-Jun N-terminal Kinase Activation
Yong Lin, Qingfeng Yang, Xia Wang, and Zheng-gang Liu
J. Biol. Chem. 2006; 281:23525-23532. [Abstract] [Full Text] [PDF]
Peroxisome Proliferator-activated Receptor -regulated ABCG2 Expression Confers Cytoprotection to Human Dendritic Cells
Istvan Szatmari, György Vámosi, Peter Brazda, Balint L. Balint, Szilvia Benko, Lajos Széles, Viktoria Jeney, Csilla Özvegy-Laczka, Attila Szántó, Endre Barta, József Balla, Balazs Sarkadi, and Laszlo Nagy
J. Biol. Chem. 2006; 281:23812-23823. [Abstract] [Full Text] [PDF]
A dominant function of IKK/NF-kB signaling in global LPS-induced gene expression
Nathalie Carayol, Ji Chen, Fan Yang, Taocong Jin, Lijian Jin, David States, and Cun-Yu Wang
published 16 August 2006, 10.1074/jbc.M603417200 [Abstract] [PDF]
Peroxisome Proliferator-activated Receptor Promotes Epithelial to Mesenchymal Transformation by Rho GTPase-dependent Activation of ERK1/2
Lu Chen, Brian M. Necela, Weidong Su, Masahiro Yanagisawa, Panos Z. Anastasiadis, Alan P. Fields, and E. Aubrey Thompson
J. Biol. Chem. 2006; 281:24575-24587. [Abstract] [Full Text] [PDF]
Dual Regulation of Rho and Rac by p120 Catenin Controls Adipocyte Plasma Membrane Trafficking
June C. Hou, Satoshi Shigematsu, Howard C. Crawford, Panos Z. Anastasiadis, and Jeffrey E. Pessin
J. Biol. Chem. 2006; 281:23307-23312. [Abstract] [Full Text] [PDF]
Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1
Lifu Wang, Christopher J. Rhodes, and John C. Lawrence, Jr.
J. Biol. Chem. 2006; 281:24293-24303. [Abstract] [Full Text] [PDF]
A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: STRUCTURE AND FUNCTION OF AN ALAB5 ANALOG
Qing-xin Hua, Ming Liu, Shi-Quan Hu, Wenhua Jia, Peter Arvan, and Michael A. Weiss
J. Biol. Chem. 2006; 281:24889-24899. [Abstract] [Full Text] [PDF]
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
Sarah M. Ronnebaum, Olga Ilkayeva, Shawn C. Burgess, Jamie W. Joseph, Danhong Lu, Robert D. Stevens, Thomas C. Becker, A. Dean Sherry, Christopher B. Newgard, and Mette V. Jensen
published 15 August 2006, 10.1074/jbc.M511908200 [Abstract] [PDF]
Role of the Activation Loop Tyrosines in Regulation of the Insulin-like Growth Factor I Receptor-tyrosine Kinase
Wanqing Li and W. Todd Miller
J. Biol. Chem. 2006; 281:23785-23791. [Abstract] [Full Text] [PDF]
If you would like to have your friends or colleagues to be a member of IRIG and receiving IRIG e-mail in the future, please feel free to contact me.
By Jianping at PBRC
-----------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Michihiro Matsumoto, Seongah Han, Tadahiro Kitamura, and Domenico Accili
published 10 August 2006, 10.1172/JCI27047 [Abstract] [PDF]
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-B activation: TAO2 regulates TAK1 pathways
Wei-Chun HuangFu, Emily Omori, Shizuo Akira, Kunihiro Matsumoto, and Jun Ninomiya-Tsuji
published 7 August 2006, 10.1074/jbc.M603627200 [Abstract] [PDF]
Dual Regulation of Rho and Rac by p120 Catenin Controls Adipocyte Plasma Membrane Trafficking
June C. Hou, Satoshi Shigematsu, Howard C. Crawford, Panos Z. Anastasiadis, and Jeffrey E. Pessin
J. Biol. Chem. 2006; 281:23307-23312. [Abstract] [Full Text] [PDF]
Identification of novel glycogen synthase kinase-3 substrate interacting residues suggests a common mechanism for substrate recognition
Ronit Ilouz, Noga Kowalsman, Miriam Eisenstein, and Hagit Eldar-Finkelman
published 7 August 2006, 10.1074/jbc.M604633200 [Abstract] [PDF]
Under-expressed coactivators PGC1 and SRC1 impair HNF4 function and promote dedifferentiation in human hepatoma cells
Celia P. Martinez-Jimenez, Marin José Gomez-Lechon, Jose V. Castell, and Ramiro Jover
published 4 August 2006, 10.1074/jbc.M604046200 [Abstract] [PDF]
PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum
Stephen S. Lin, Michael C. Bassik, Heikyung Suh, Mari Nishino, Jason D. Arroyo, William C. Hahn, Stanley J. Korsmeyer, and Thomas M. Roberts
J. Biol. Chem. 2006; 281:23003-23012. [Abstract] [Full Text] [PDF]
Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet -cells. VOLUME 281 (2006) PAGES 15884-15892
Melissa K. Lingohr, Isabelle Briaud, Lorna M. Dickson, Jill F. McCuaig, Cristina Alarcón, Barton L. Wicksteed, and Christopher J. Rhodes
J. Biol. Chem. 2006; 281:23296-a. [Full Text] [PDF]
The Essential Role of the Death Domain Kinase Receptor-interacting Protein in Insulin Growth Factor-I-induced c-Jun N-terminal Kinase Activation
Yong Lin, Qingfeng Yang, Xia Wang, and Zheng-gang Liu
J. Biol. Chem. 2006; 281:23525-23532. [Abstract] [Full Text] [PDF]
Peroxisome Proliferator-activated Receptor -regulated ABCG2 Expression Confers Cytoprotection to Human Dendritic Cells
Istvan Szatmari, György Vámosi, Peter Brazda, Balint L. Balint, Szilvia Benko, Lajos Széles, Viktoria Jeney, Csilla Özvegy-Laczka, Attila Szántó, Endre Barta, József Balla, Balazs Sarkadi, and Laszlo Nagy
J. Biol. Chem. 2006; 281:23812-23823. [Abstract] [Full Text] [PDF]
A dominant function of IKK/NF-kB signaling in global LPS-induced gene expression
Nathalie Carayol, Ji Chen, Fan Yang, Taocong Jin, Lijian Jin, David States, and Cun-Yu Wang
published 16 August 2006, 10.1074/jbc.M603417200 [Abstract] [PDF]
Peroxisome Proliferator-activated Receptor Promotes Epithelial to Mesenchymal Transformation by Rho GTPase-dependent Activation of ERK1/2
Lu Chen, Brian M. Necela, Weidong Su, Masahiro Yanagisawa, Panos Z. Anastasiadis, Alan P. Fields, and E. Aubrey Thompson
J. Biol. Chem. 2006; 281:24575-24587. [Abstract] [Full Text] [PDF]
Dual Regulation of Rho and Rac by p120 Catenin Controls Adipocyte Plasma Membrane Trafficking
June C. Hou, Satoshi Shigematsu, Howard C. Crawford, Panos Z. Anastasiadis, and Jeffrey E. Pessin
J. Biol. Chem. 2006; 281:23307-23312. [Abstract] [Full Text] [PDF]
Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1
Lifu Wang, Christopher J. Rhodes, and John C. Lawrence, Jr.
J. Biol. Chem. 2006; 281:24293-24303. [Abstract] [Full Text] [PDF]
A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: STRUCTURE AND FUNCTION OF AN ALAB5 ANALOG
Qing-xin Hua, Ming Liu, Shi-Quan Hu, Wenhua Jia, Peter Arvan, and Michael A. Weiss
J. Biol. Chem. 2006; 281:24889-24899. [Abstract] [Full Text] [PDF]
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
Sarah M. Ronnebaum, Olga Ilkayeva, Shawn C. Burgess, Jamie W. Joseph, Danhong Lu, Robert D. Stevens, Thomas C. Becker, A. Dean Sherry, Christopher B. Newgard, and Mette V. Jensen
published 15 August 2006, 10.1074/jbc.M511908200 [Abstract] [PDF]
Role of the Activation Loop Tyrosines in Regulation of the Insulin-like Growth Factor I Receptor-tyrosine Kinase
Wanqing Li and W. Todd Miller
J. Biol. Chem. 2006; 281:23785-23791. [Abstract] [Full Text] [PDF]
If you would like to have your friends or colleagues to be a member of IRIG and receiving IRIG e-mail in the future, please feel free to contact me.
By Jianping at PBRC
-----------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: ATGL in Science and PTP1B in Nature Medicine
10/04/2006 07:41 Filed in: 2006
Adipose triglyceride lipase (ATGL), highly expressed
in adipose tissue, is associated with lipid droplets
inside cells. The function of ATGL is to specifically
hydrolyze triacylglycerol (TG) into free fatty acids.
ATGL is the second TG lipase next to the hormone
sensitive lipase (HSL) in adipose tissue for
hydrolysis of TG. In a recent issue of Science, the
phenotype of ATGL knockout mice was published. The
knockout leads to an increase in adipose mass and
triacylglycerol deposition in multiple tissues
including heart, causing cardiac dysfunction and
premature death. The mice had increased glucose
utilization, increased glucose tolerance, and
increased insulin sensitivity. Like CD36 KO mice,
this is another example that less utilization of FFA
may lead to insulin sensitization. Attached is the
PDF file of the paper.
PTP1B is a tyrosine phosphatase that was shown to inhibit signaling activities of leptin and insulin receptors. Mice with global inactivation of PTP1B exhibit higher sensitivity to leptin and do not develop diet-induced obesity. However, the organ/tissue responsible for the metabolic phenotype of TP1B inactivation is not known. In Nature Medicine online publications, a new study using tissue-specific KO mice of PTP1B demonstrates that the brain is the organ. See attached PDF file.
ATGL paper in Science
PTP1B paper in Nature Medicine
By Jianping at PBRC
*----------------------------------------------------
ATGL is Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
PTP1B is a tyrosine phosphatase that was shown to inhibit signaling activities of leptin and insulin receptors. Mice with global inactivation of PTP1B exhibit higher sensitivity to leptin and do not develop diet-induced obesity. However, the organ/tissue responsible for the metabolic phenotype of TP1B inactivation is not known. In Nature Medicine online publications, a new study using tissue-specific KO mice of PTP1B demonstrates that the brain is the organ. See attached PDF file.
ATGL paper in Science
PTP1B paper in Nature Medicine
By Jianping at PBRC
*----------------------------------------------------
ATGL is Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: p53-glycolysis in "Cell"
10/04/2006 07:40 Filed in: 2006
On June 22th, a paper in "Science" was highlighted in
our IRIG communication. This paper suggests that the
transcription factor p53, a tumor suppressor gene
product, is able to inhibit glycolysis in normal
cells by induction of SCO2 (Synthesis of Cytochrome c
Oxidase 2). When p53 function is absent in tumor
cells, such as in cancer patient with p53 mutation,
SCO2 expression is down and thus glycolysis activity
is up. This switch may contribute to the malignancy
of tumor cells since they can grow under low level of
oxygen. In the current issue of "Cell", this function
of p53 is reenforced by another study. This cell
paper shows that p53 inhibits glycolysis through
regulation of gene transcription. However, p53 was
shown to act through a new target gene "Tigar"
(TP53-induced glycolysis and apoptosis regulator).
This study was highlighted in a preview in the same
issue of "Cell". Attached are PDF files of those
papers.
The two studies in "Science" and "Cell" consistently suggests that glucose metabolism influences risk of cancer. If your gene background gives you a strong p53 function, you may have a low risk of cancer. However, the glycolysis activity might be low in your body. This may increase the risk of insulin resistance, type 2 diabetes, and cardiovascular diseases. This view is supported by the fact that metaformin is able to promote longevity and this drug stimulates glycolysis leading to insulin sensitization. The correlation may provide a clue for the molecular mechanism of aging.
P53 and tigar by Bensaad.
P53 and tigar previewed by Green.
P53 regulates mitochondrial respiration.
by Jianping at PBRC
*------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
The two studies in "Science" and "Cell" consistently suggests that glucose metabolism influences risk of cancer. If your gene background gives you a strong p53 function, you may have a low risk of cancer. However, the glycolysis activity might be low in your body. This may increase the risk of insulin resistance, type 2 diabetes, and cardiovascular diseases. This view is supported by the fact that metaformin is able to promote longevity and this drug stimulates glycolysis leading to insulin sensitization. The correlation may provide a clue for the molecular mechanism of aging.
P53 and tigar by Bensaad.
P53 and tigar previewed by Green.
P53 regulates mitochondrial respiration.
by Jianping at PBRC
*------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Interesting papers in JBC
10/04/2006 07:40 Filed in: 2006
Diminished Hepatic Gluconeogenesis via Defects in
Tricarboxylic Acid Cycle Flux in Peroxisome
Proliferator-activated Receptor Coactivator-1
(PGC-1)-deficient Mice
Shawn C. Burgess, Teresa C. Leone, Adam R. Wende, Michelle A. Croce, Zhouji Chen, A. Dean Sherry, Craig R. Malloy, and Brian N. Finck J. Biol. Chem. 2006; 281:19000-19008. [Abstract] [Full Text] [PDF]
Aicar-induced AMPK phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes
Mandeep Pinky Gaidhu, Sergiu Fediuc, and Rolando Bacis Ceddia published 1 July 2006, 10.1074/jbc.M602992200 [Abstract] [PDF]
The role of Src kinase in insulin-like growth factor dependent mitogenic signaling in vascular smooth muscle cells
Jaroslava Lieskovska, Yan Ling, Jane Badley-Clarke, and David R. Clemmons published 5 July 2006, 10.1074/jbc.M602866200 [Abstract] [PDF]
Endoplasmic Reticulum Stress Induction of Insulin-like Growth Factor-binding Protein-1 Involves ATF4
Alexandre Marchand, Céline Tomkiewicz, Laurent Magne, Robert Barouki, and Michèle Garlatti J. Biol. Chem. 2006; 281:19124-19133. [Abstract] [Full Text] [PDF]
Caveolin-1 Functions as a Novel Cdc42 Guanine Nucleotide Dissociation Inhibitor in Pancreatic -Cells
Angela K. Nevins and Debbie C. Thurmond J. Biol. Chem. 2006; 281:18961-18972. [Abstract] [Full Text] [PDF]
Regulation of constitutive androstane receptor and its target genes by fasting, cyclic AMP, HNF-4 and the coactivator PGC-1
Xunshan Ding, Kristin Lichti, Insook Kim, Frank J. Gonzalez, and Jeff L. Staudinger published 5 July 2006, 10.1074/jbc.M600931200 [Abstract] [PDF]
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle
Tonya L. Martin, Thierry Alquier, Kenji Asakura, Noboru Furukawa, Frederic Preitner, and Barbara B. Kahn J. Biol. Chem. 2006; 281:18933-18941. [Abstract] [Full Text] [PDF]
The Alternative Stimulatory G Protein -Subunit XLs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult Mice
Tao Xie, Antonius Plagge, Oksana Gavrilova, Stephanie Pack, William Jou, Edwin W. Lai, Marga Frontera, Gavin Kelsey, and Lee S. Weinstein J. Biol. Chem. 2006; 281:18989-18999. [Abstract] [Full Text] [PDF]
By Jianping at PBRC
-----------------—-
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Shawn C. Burgess, Teresa C. Leone, Adam R. Wende, Michelle A. Croce, Zhouji Chen, A. Dean Sherry, Craig R. Malloy, and Brian N. Finck J. Biol. Chem. 2006; 281:19000-19008. [Abstract] [Full Text] [PDF]
Aicar-induced AMPK phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes
Mandeep Pinky Gaidhu, Sergiu Fediuc, and Rolando Bacis Ceddia published 1 July 2006, 10.1074/jbc.M602992200 [Abstract] [PDF]
The role of Src kinase in insulin-like growth factor dependent mitogenic signaling in vascular smooth muscle cells
Jaroslava Lieskovska, Yan Ling, Jane Badley-Clarke, and David R. Clemmons published 5 July 2006, 10.1074/jbc.M602866200 [Abstract] [PDF]
Endoplasmic Reticulum Stress Induction of Insulin-like Growth Factor-binding Protein-1 Involves ATF4
Alexandre Marchand, Céline Tomkiewicz, Laurent Magne, Robert Barouki, and Michèle Garlatti J. Biol. Chem. 2006; 281:19124-19133. [Abstract] [Full Text] [PDF]
Caveolin-1 Functions as a Novel Cdc42 Guanine Nucleotide Dissociation Inhibitor in Pancreatic -Cells
Angela K. Nevins and Debbie C. Thurmond J. Biol. Chem. 2006; 281:18961-18972. [Abstract] [Full Text] [PDF]
Regulation of constitutive androstane receptor and its target genes by fasting, cyclic AMP, HNF-4 and the coactivator PGC-1
Xunshan Ding, Kristin Lichti, Insook Kim, Frank J. Gonzalez, and Jeff L. Staudinger published 5 July 2006, 10.1074/jbc.M600931200 [Abstract] [PDF]
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle
Tonya L. Martin, Thierry Alquier, Kenji Asakura, Noboru Furukawa, Frederic Preitner, and Barbara B. Kahn J. Biol. Chem. 2006; 281:18933-18941. [Abstract] [Full Text] [PDF]
The Alternative Stimulatory G Protein -Subunit XLs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult Mice
Tao Xie, Antonius Plagge, Oksana Gavrilova, Stephanie Pack, William Jou, Edwin W. Lai, Marga Frontera, Gavin Kelsey, and Lee S. Weinstein J. Biol. Chem. 2006; 281:18989-18999. [Abstract] [Full Text] [PDF]
By Jianping at PBRC
-----------------—-
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Outstanding reviews in JCI
10/04/2006 07:36 Filed in: 2006
In the current issue of JCI (Journal of Clinical
Investigation), a series of review articles are
published to address the hot areas in metabolic
syndrome. Following is a highlight of the reviews.
—---------------------------------------------------------------------
Insulin resistance and atherosclerosis
Clay F. Semenkovich
J. Clin. Invest. 2006; 116:1813-1822. [Abstract] [Full Text] [PDF]
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara, Kohjiro Ueki, and Kazuyuki Tobe
J. Clin. Invest. 2006; 116:1784-1792. [Abstract] [Full Text] [PDF]
Inflammation and insulin resistance
Steven E. Shoelson, Jongsoon Lee, and Allison B. Goldfine
J. Clin. Invest. 2006; 116:1793-1801. [Abstract] [Full Text] [PDF]
Islet ß cell failure in type 2 diabetes
Marc Prentki and Christopher J. Nolan
J. Clin. Invest. 2006; 116:1802-1812. [Abstract] [Full Text] [PDF]
Central insulin action in energy and glucose homeostasis
Leona Plum, Bengt F. Belgardt, and Jens C. Brüning
J. Clin. Invest. 2006; 116:1761-1766. [Abstract] [Full Text] [PDF]
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Leona Plum, Xiaosong Ma, Brigitte Hampel, Nina Balthasar, Roberto Coppari, Heike Münzberg, Marya Shanabrough, Denis Burdakov, Eva Rother, Ruth Janoschek, Jens Alber, Bengt F. Belgardt, Linda Koch, Jost Seibler, Frieder Schwenk, Csaba Fekete, Akira Suzuki, Tak W. Mak, Wilhelm Krone, Tamas L. Horvath, Frances M. Ashcroft, and Jens C. Brüning
J. Clin. Invest. 2006; 116:1886-1901. [Abstract] [Full Text] [PDF]
Insulin resistance and pancreatic ß cell failure
Masato Kasuga
J. Clin. Invest. 2006; 116:1756-1760. [Abstract] [Full Text] [PDF]
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
Mark A. Herman and Barbara B. Kahn
J. Clin. Invest. 2006; 116:1767-1775. [Abstract] [Full Text] [PDF]
by Jianping at PBRC
—------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
—---------------------------------------------------------------------
Insulin resistance and atherosclerosis
Clay F. Semenkovich
J. Clin. Invest. 2006; 116:1813-1822. [Abstract] [Full Text] [PDF]
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara, Kohjiro Ueki, and Kazuyuki Tobe
J. Clin. Invest. 2006; 116:1784-1792. [Abstract] [Full Text] [PDF]
Inflammation and insulin resistance
Steven E. Shoelson, Jongsoon Lee, and Allison B. Goldfine
J. Clin. Invest. 2006; 116:1793-1801. [Abstract] [Full Text] [PDF]
Islet ß cell failure in type 2 diabetes
Marc Prentki and Christopher J. Nolan
J. Clin. Invest. 2006; 116:1802-1812. [Abstract] [Full Text] [PDF]
Central insulin action in energy and glucose homeostasis
Leona Plum, Bengt F. Belgardt, and Jens C. Brüning
J. Clin. Invest. 2006; 116:1761-1766. [Abstract] [Full Text] [PDF]
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Leona Plum, Xiaosong Ma, Brigitte Hampel, Nina Balthasar, Roberto Coppari, Heike Münzberg, Marya Shanabrough, Denis Burdakov, Eva Rother, Ruth Janoschek, Jens Alber, Bengt F. Belgardt, Linda Koch, Jost Seibler, Frieder Schwenk, Csaba Fekete, Akira Suzuki, Tak W. Mak, Wilhelm Krone, Tamas L. Horvath, Frances M. Ashcroft, and Jens C. Brüning
J. Clin. Invest. 2006; 116:1886-1901. [Abstract] [Full Text] [PDF]
Insulin resistance and pancreatic ß cell failure
Masato Kasuga
J. Clin. Invest. 2006; 116:1756-1760. [Abstract] [Full Text] [PDF]
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
Mark A. Herman and Barbara B. Kahn
J. Clin. Invest. 2006; 116:1767-1775. [Abstract] [Full Text] [PDF]
by Jianping at PBRC
—------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: MicroRNA and Knockout mice in "Nature Genetics" and"Science"
10/04/2006 07:26 Filed in: 2006
MicroRNA is a natural RNA product with 19-22
nucleotides in length. It works as a RNAi in the
regulation of gene expression. However, it is not
made by man. It is made from genomic DNA and involved
in gene regulation cross species. MicroRNA represents
a new layer of post-transcriptional regulation in the
body. "Nature Genetics" published a supplement issue
to address microRNA-related questions, such as what
is microRNA? How to study it? Following is the link
to this free issue of Nature Genetics - microRNA
supplement.
Click here to access:
http://info.nature.com/cgi-bin24/DM/y/eYp70BiDI60Ct027U0E5
Genomic DNA has been completely sequenced for human and mouse. The next qeustion is the functions of genes. To address this issue in a big way, Europe, Canada, USA and China have made huge plans to generate 60,000 knockout mice together. This is reported in the current issue of "Science" at following link:
http://www.sciencemag.org/cgi/content/summary/312/5782/1862?etoc. Hopefully, in the future, lab scientists can buy KO mice easily.
By Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Click here to access:
http://info.nature.com/cgi-bin24/DM/y/eYp70BiDI60Ct027U0E5
Genomic DNA has been completely sequenced for human and mouse. The next qeustion is the functions of genes. To address this issue in a big way, Europe, Canada, USA and China have made huge plans to generate 60,000 knockout mice together. This is reported in the current issue of "Science" at following link:
http://www.sciencemag.org/cgi/content/summary/312/5782/1862?etoc. Hopefully, in the future, lab scientists can buy KO mice easily.
By Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Papers in "Science"
10/04/2006 07:21 Filed in: 2006
Activation of PPARg in the adipose tissue is
associated with the insulin sensitizing activity of
TZDs. Activation of PPARg in the liver has been
associated with the side effects of TZDs as liver
toxicity is a major problem of TZDs. In the current
issue of "Science", this concept is challenged by a
study that hepatic PPARg may stimulate energy
expenditure in the peripheral adipose tissue through
a new pathway: liver-nerve-fat. The activity of this
pathway in peripheral energy expenditure is promoted
by TZDs. See details in
attached PDF file. This paper is recommended by
Dr. Jianhua Shao at the Graduate Center for
Nutritional Sciences, University of Kentucky,
Lexington.
Mitochondrial function is associated with oxygen-dependent ATP production. In tumor cells, this ATP production pathway is usually replaced by glycolysis. Does this switch involve in tumor suppresser gene? The answer is yes. In "Science", a study shows that p53 mutation promotes such a switch through a protein by the name of Synthesis of Cytochrome c Oxidase 2 (SCO2). Expression of this protein prevents the switch. p53 function is required for the expression of this protein. See attached PDF file.
by Jianping at PBRC
*----------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Mitochondrial function is associated with oxygen-dependent ATP production. In tumor cells, this ATP production pathway is usually replaced by glycolysis. Does this switch involve in tumor suppresser gene? The answer is yes. In "Science", a study shows that p53 mutation promotes such a switch through a protein by the name of Synthesis of Cytochrome c Oxidase 2 (SCO2). Expression of this protein prevents the switch. p53 function is required for the expression of this protein. See attached PDF file.
by Jianping at PBRC
*----------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Some interesting papers in JBC
10/03/2006 22:42 Filed in: 2006
Increased CUG triplet repeat binding protein-1
predisposes to impaired adipogenesis with aging
Iordanes Karagiannides, Thomas Thomou, Tamara
Tchkonia, Tamar Pirtskhalava, Kyriakos E. Kypreos,
Andrew Cartwright, Georgia Dalagiorgou, Timothy L.
Lash, Stephen R. Farmer, Nikolai A. Timchenko,
and James L. Kirkland published 5 June 2006, 10.1074/jbc.M513187200 [Abstract] [PDF]
Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking June Chunqiu Hou, Satoshi Shigematsu, Howard C. Crawford, Panos Z. Anastasiadis, and Jeffrey E. Pessin published 5 June 2006, 10.1074/jbc.M603127200 [Abstract] [PDF]
Glucose acutely decreases pH of secretory granules in mouse pancreatic islets: mechanisms and influence on insulin secretion
Patrick Stiernet, Yves Guiot, Patrick Gilon, and Jean-Claude Henquin published 7 June 2006, 10.1074/jbc.M513224200 [Abstract] [PDF]
Akt Regulates Basal and Induced Processing of NF-B2 (p100) to p52 Jason A. Gustin, Chandrashekhar K. Korgaonkar, Roxana Pincheira, Qiutang Li, and David B. Donner J. Biol. Chem. 2006; 281:16473-16481. [Abstract] [Full Text] [PDF]
Nuclear Export of Retinoid X Receptor in Response to Interleukin-1-mediated Cell Signaling: ROLES FOR JNK AND SER260
Tracy L. Zimmerman, Sundararajah Thevananther, Romi Ghose, Alan R. Burns, and Saul J. Karpen
J. Biol. Chem. 2006; 281:15434-15440. [Abstract] [Full Text] [PDF]
Heparin synergistically enhances interleukin-11 signaling through upregulation of the MAP kinase pathway
Raghav Rajgopal, Martin Butcher, Jeffrey I. Weitz, and Stephen G. Shaughnessy
published 23 May 2006, 10.1074/jbc.M600169200 [Abstract] [PDF]
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
and James L. Kirkland published 5 June 2006, 10.1074/jbc.M513187200 [Abstract] [PDF]
Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking June Chunqiu Hou, Satoshi Shigematsu, Howard C. Crawford, Panos Z. Anastasiadis, and Jeffrey E. Pessin published 5 June 2006, 10.1074/jbc.M603127200 [Abstract] [PDF]
Glucose acutely decreases pH of secretory granules in mouse pancreatic islets: mechanisms and influence on insulin secretion
Patrick Stiernet, Yves Guiot, Patrick Gilon, and Jean-Claude Henquin published 7 June 2006, 10.1074/jbc.M513224200 [Abstract] [PDF]
Akt Regulates Basal and Induced Processing of NF-B2 (p100) to p52 Jason A. Gustin, Chandrashekhar K. Korgaonkar, Roxana Pincheira, Qiutang Li, and David B. Donner J. Biol. Chem. 2006; 281:16473-16481. [Abstract] [Full Text] [PDF]
Nuclear Export of Retinoid X Receptor in Response to Interleukin-1-mediated Cell Signaling: ROLES FOR JNK AND SER260
Tracy L. Zimmerman, Sundararajah Thevananther, Romi Ghose, Alan R. Burns, and Saul J. Karpen
J. Biol. Chem. 2006; 281:15434-15440. [Abstract] [Full Text] [PDF]
Heparin synergistically enhances interleukin-11 signaling through upregulation of the MAP kinase pathway
Raghav Rajgopal, Martin Butcher, Jeffrey I. Weitz, and Stephen G. Shaughnessy
published 23 May 2006, 10.1074/jbc.M600169200 [Abstract] [PDF]
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: IL-18 and RNAi in "Nature"
10/03/2006 22:33 Filed in: 2006
Interleukin 18 (IL-18) is a pro-inflammatory cytokine
which participates in host defense against a variety
of infections, chronic inflammation and autoimmune
diseases. In "Nature Medicine", a report provide
evidence that in the IL-18 knockout mice, obesity is
resulted from hyperphagia, and a defect in STAT3
signaling is attributed to the hyperphagia. STAT3
deficiency is due to lack of phopshorylation. The
hyperphagia-obesity leads to insulin resistance in
the KO mice. This is a new model that immune system
may regulate energy balance (See attached PDF file).
The existing models include IL-6 KO mice that have a
similar metabolic phenotype to this IL-18 KO mice.
RNA interference (RNAi) is a common tool in the analysis of gene function in vitro. In vivo application of RNAi was believed to hold promise for treatment of diseases. However, non-specific activity of RNAi has drawn more and more attention. This is especially important for in vivo study. In "Nature", a report shows that over-expression of RNAi in liver may cause death in mice. This toxic effect was observed in 36 out of 49 RNAi expression systems that were made using adenovirus delivery system. This study suggests that consistent high-level expression of RNAi in transgenic mice may induce non-specific or toxic effect in vivo. For details, see attached PDF file. This paper is recommended by Dr. Bing Sun at the Otsuka Maryland Medicinal Laboratories.
IL-18 obesity and insulin resistance
RNAi and fatality
By Jianping at PBRC
*-------------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
RNA interference (RNAi) is a common tool in the analysis of gene function in vitro. In vivo application of RNAi was believed to hold promise for treatment of diseases. However, non-specific activity of RNAi has drawn more and more attention. This is especially important for in vivo study. In "Nature", a report shows that over-expression of RNAi in liver may cause death in mice. This toxic effect was observed in 36 out of 49 RNAi expression systems that were made using adenovirus delivery system. This study suggests that consistent high-level expression of RNAi in transgenic mice may induce non-specific or toxic effect in vivo. For details, see attached PDF file. This paper is recommended by Dr. Bing Sun at the Otsuka Maryland Medicinal Laboratories.
IL-18 obesity and insulin resistance
RNAi and fatality
By Jianping at PBRC
*-------------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Protein tyrosine phosphatase in "Nature" and "Cell Metabolism"
10/03/2006 22:23 Filed in: 2006
Tyrosine phosphorylation of IRS-1/2 (insulin receptor
substrate 1 or 2) is an activation signal in the
signal transduction pathway of insulin receptor. The
phosphorylation is catalyzed by the beta-subunits of
insulin receptor that is formed by two alpha and two
beta subunits. The beta subunits are
auto-phosphorylated on tyrosine residues and thus
become activated upon insulin engagement with the
alpha subunit. Tyrosine phopshorylation of IRS-1/2
leads to activation of down-stream signaling molecule
PI3K by recruiting the regulatory subunit p85.
Tyrosine phosphorylation in IRS and IR is require for
insulin action and subject to regulation by tyrosine
de-phosphorylation. Several tyrosine phosphatases
have been identified for inhibition of these tyrosine
phosphorylation-mediated events, such as PTP-1B whose
activity contributes to insulin resistance. In Nature
and Cell Metabolism, two more protein tyrosine
phosphatases were reported to regulate insulin action
especially in the liver: one is SHP-1 and the other
is PTP-MEG2. See attached PDF files.
HP-1 and insulin signaling by Dubois 2006.pdf (417541 bytes)
PTP-MEG2 and insulin signaling by Cho 2006.pdf (570369 bytes)
By Jianping at PBRC
*-----------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
HP-1 and insulin signaling by Dubois 2006.pdf (417541 bytes)
PTP-MEG2 and insulin signaling by Cho 2006.pdf (570369 bytes)
By Jianping at PBRC
*-----------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Papers in Science and Nature Genetics
10/03/2006 22:15 Filed in: 2006
Glucose and fatty acids are the major fuels in the
body. A decrease in one consumption leads to an
increase in consumption of the other one. Although
this principal is not new, the mechanism for such
balance is quit interesting. Previous study suggests
that a reduction in fatty acid uptake by cells leads
to an increase in glucose utilization and insulin
sensitization. This was demonstrated in CD36 (fatty
acid transporter) knockout mice. Now, a new study in "Science" suggests
that a reduction in triglyceride hydrolysis also
give such a phenotype in transgenic mice. This
was demonstrated using the knockout mice for
ATGL (adipocyte triglyceride lipase), an enzyme
highly expressed in adipocytes to catalyze
hydrolysis of triglycerides (TG). See attached
PDF file.
PI3K/Akt signaling pathway is used by insulin and IGF-1 to stimulate cell growth in many type of tissues including muscle, fat and liver. In Nature Genetics, two studies using different approaches consistently demonstrate that this signaling pathway is required for beta-cell proliferation and islet mass. Knockout of insulin receptor plus IGF-1 receptor, or PDK1 (a PI3K downstream kinase) alone leads to islet atrophy and diabetes. The studies provide new support that insulin resistance in beta cells may contribute to beta-cell dysfunction in type 2 diabetes. Attached are PDF of the two papers.
By Jianping at PBRC
*--------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
PI3K/Akt signaling pathway is used by insulin and IGF-1 to stimulate cell growth in many type of tissues including muscle, fat and liver. In Nature Genetics, two studies using different approaches consistently demonstrate that this signaling pathway is required for beta-cell proliferation and islet mass. Knockout of insulin receptor plus IGF-1 receptor, or PDK1 (a PI3K downstream kinase) alone leads to islet atrophy and diabetes. The studies provide new support that insulin resistance in beta cells may contribute to beta-cell dysfunction in type 2 diabetes. Attached are PDF of the two papers.
By Jianping at PBRC
*--------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Science paper: Amino acid sensing in Brain
10/03/2006 22:12 Filed in: 2006
A study published in the current issue of Science" suggests a mechanism by
which amino acids regulate food intake. Amino
acid leucine was shown to inhibit food intake
through activation of mTOR (Mammalian Target Of
Rapamycin), a serine kinase in the insulin
signaling pathway. Leptin may also use this
mechanism in the regulation of food intake. This
study is highlighted in Today's "The Scientist"
at following link: Attached (1) is the PDF file of
this Science paper.
In addition, a study in JCI provides more support about MCP-1 (Monocyte Chemoattractant Protein 1) in macrophage infiltration in adipose tissue in obesity. Fat-specific over-expression of MCP-1 led to an increase in macrophage infiltration in fat, systemic insulin resistance and TG accumulation in liver. Global knockout of MCP-1 reduced the infiltration in mice. The conclusion is consistent with the phenotype of MCP-1 receptor (CCR2) KO mice published last year in JCI. Attached (2) is the PDF file of this paper.
By Jianping at PBRC
*------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
In addition, a study in JCI provides more support about MCP-1 (Monocyte Chemoattractant Protein 1) in macrophage infiltration in adipose tissue in obesity. Fat-specific over-expression of MCP-1 led to an increase in macrophage infiltration in fat, systemic insulin resistance and TG accumulation in liver. Global knockout of MCP-1 reduced the infiltration in mice. The conclusion is consistent with the phenotype of MCP-1 receptor (CCR2) KO mice published last year in JCI. Attached (2) is the PDF file of this paper.
By Jianping at PBRC
*------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: CRP, Adiponectin, STAT5 in "Nature" and "Nature Cell Biology"
10/03/2006 22:10 Filed in: 2006
In the current issue of "Nature", a study suggests that a
chemical inhibitor of CRP (C-reactive protein)
is able to protect
cardiovascular system, and treat cardiovascular diseases (CVDs). This study reports a novel CRP inhibitor and provides a strong support that CRP contributes the pathogenesis of CVDs. CRP was shown to cause leptin resistance recently in a study in Nature Medicine (IRIG post on 4/6/06).
In the "Nature Cell Biology", there are two interesting papers. The first study reports a new signaling molecule for adiponectin receptor. This is an adaptor protein by the name of APPL1 that interacts with adiponectin receptor and mediates signals of the receptor. Adiponectin induces recruitment of APPL1 to the receptor, and inhibitionof APPL1 blocks the signaling pathway of adiponnectin.
The second study reports that the transcription factor STAT5 is involved in insulin secretion in beta-cells. The study provides moecular connection for synergy between glucose and growth hormone in theregulation of insulin secretion. STAT5 mediates growth hormone signals.
Attached are PDF files of the these papers above.
By Jianping at PBRC
--------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
cardiovascular system, and treat cardiovascular diseases (CVDs). This study reports a novel CRP inhibitor and provides a strong support that CRP contributes the pathogenesis of CVDs. CRP was shown to cause leptin resistance recently in a study in Nature Medicine (IRIG post on 4/6/06).
In the "Nature Cell Biology", there are two interesting papers. The first study reports a new signaling molecule for adiponectin receptor. This is an adaptor protein by the name of APPL1 that interacts with adiponectin receptor and mediates signals of the receptor. Adiponectin induces recruitment of APPL1 to the receptor, and inhibitionof APPL1 blocks the signaling pathway of adiponnectin.
The second study reports that the transcription factor STAT5 is involved in insulin secretion in beta-cells. The study provides moecular connection for synergy between glucose and growth hormone in theregulation of insulin secretion. STAT5 mediates growth hormone signals.
Attached are PDF files of the these papers above.
By Jianping at PBRC
--------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: ROS in Insulin Resistance (Nature)
10/03/2006 22:09 Filed in: 2006
Reactive oxygen species (ROS or free radicals) are
signal mediators in physiological condition. Over
production of ROS is able to induce many side effects
such as cell apoptosis, inflammation, and gene
mutation, which has been well documented in cancer,
immunology and aging fields. A role of ROS in the
pathogenesis of insulin resistance has been
speculated for some times. However, there was no
direct evidence to support this possibility. This
condition is changed by a new study in the current
issue of Nature. The report suggests that ROS is
required for development of insulin resistance in
response to TNF-alpha or glucocortcoide hormone.
Attached is the paper that is recommended by Dr.
Hong-Ping Guan at UT Southwestern Medical Center.
(Attachment 1)
ROS is able to activate signaling molecules such as JNK, and NF-kB, which are known to contribute to insulin resistance. In Nature Medicine, a study shows that ROS is able to activate MAP kinase p38 to reduce life span of hemopoietic stem cells (Attachment 2).
By Jianping at PBRC
-------------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
ROS is able to activate signaling molecules such as JNK, and NF-kB, which are known to contribute to insulin resistance. In Nature Medicine, a study shows that ROS is able to activate MAP kinase p38 to reduce life span of hemopoietic stem cells (Attachment 2).
By Jianping at PBRC
-------------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: More interesting papers in Nature Medicine
10/03/2006 22:08 Filed in: 2006
In the last post, the new study of leptin resistance
in Nature Medicine was highlighted with PDF file.
Here, we list three more
metabolism related papers published online in Nature Medicine. These studies provide new insight in the mechanisms of central control of food intake and AMPK activation in muscle. Following is the list.
By Jianping at PBRC and Feng at the Health Science Center at San Antonio, UT.
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
Tadahiro Kitamura, Yun Feng, Yukari Ido Kitamura, Streamson C Chua Jr, Allison W Xu, Gregory S Barsh, Luciano Rossetti & Domenico Accili
Published online: 09 April 2006 | doi:10.1038/nm1392
Abstract | Full text | PDF (490K) | Supplementary Information
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz & Xiao-Jiang Li
Published online: 09 April 2006 | doi:10.1038/nm1382
Abstract | Full text | PDF (676K) | Supplementary Information
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose-John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio & Gregory R Steinberg
Published online: 09 April 2006 | doi:10.1038/nm1383
Abstract | Full text | PDF (280K) | Supplementary Information
_________________________
Feng Liu, Ph.D.
Professor
Department of Pharmacology
Univ of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio, TX 78229
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
metabolism related papers published online in Nature Medicine. These studies provide new insight in the mechanisms of central control of food intake and AMPK activation in muscle. Following is the list.
By Jianping at PBRC and Feng at the Health Science Center at San Antonio, UT.
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
Tadahiro Kitamura, Yun Feng, Yukari Ido Kitamura, Streamson C Chua Jr, Allison W Xu, Gregory S Barsh, Luciano Rossetti & Domenico Accili
Published online: 09 April 2006 | doi:10.1038/nm1392
Abstract | Full text | PDF (490K) | Supplementary Information
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz & Xiao-Jiang Li
Published online: 09 April 2006 | doi:10.1038/nm1382
Abstract | Full text | PDF (676K) | Supplementary Information
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose-John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio & Gregory R Steinberg
Published online: 09 April 2006 | doi:10.1038/nm1383
Abstract | Full text | PDF (280K) | Supplementary Information
_________________________
Feng Liu, Ph.D.
Professor
Department of Pharmacology
Univ of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio, TX 78229
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Hepatic STAT3 in brain-insulin action on hepatic glucose production
10/03/2006 22:06 Filed in: 2006
This paper published on "Cell Metabolism" titled "
Role of hepatic STAT3 in brain-insulin action on
hepatic glucose production" demonstrated a possible
signaling target of insulin in brain which relays the
suppression of gluconeogenesis onto liver. When STAT3
is knocked down in liver, the suppression of i.c.v.
insulin on gluconeogenesis in liver is ameliorated.
This suggests that the communication between brain
and liver might target on STAT3 pathway.
Here is the link of the paper Cell Metabolism
Here is the link of the paper Cell Metabolism
IRIG: Papers in JAMA and JCI
10/03/2006 22:04 Filed in: 2006
Following are interesting papers in JAMA and JCI for
glucose and fat metabolism.
By Jianping at PBRC
-------------------------------------------------
Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial
Leonie K. Heilbronn, Lilian de Jonge, Madlyn I. Frisard, James P. DeLany, D. Enette Larson-Meyer, Jennifer Rood, Tuong Nguyen, Corby K. Martin, Julia Volaufova, Marlene M. Most, Frank L. Greenway, Steven R. Smith, Walter A. Deutsch, Donald A. Williamson, Eric Ravussin for the Pennington CALERIE Team
JAMA. 2006; 295:1539-1548. [Abstract]
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Xueliang Du, Diane Edelstein, Silvana Obici, Ninon Higham, Ming-Hui Zou, and Michael Brownlee
J. Clin. Invest. 2006; 116:1071-1080. [Abstract]
Farnesoid X receptor is essential for normal glucose homeostasis
Ke Ma, Pradip K. Saha, Lawrence Chan, and David D. Moore
J. Clin. Invest. 2006; 116:1102-1109. [Abstract]
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Alessandro Pocai, Tony K.T. Lam, Silvana Obici, Roger Gutierrez-Juarez, Evan D. Muse, Arduino Arduini, and Luciano Rossetti
J. Clin. Invest. 2006; 116:1081-1091. [Abstract]
By Jianping at PBRC
-------------------------------------------------
Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial
Leonie K. Heilbronn, Lilian de Jonge, Madlyn I. Frisard, James P. DeLany, D. Enette Larson-Meyer, Jennifer Rood, Tuong Nguyen, Corby K. Martin, Julia Volaufova, Marlene M. Most, Frank L. Greenway, Steven R. Smith, Walter A. Deutsch, Donald A. Williamson, Eric Ravussin for the Pennington CALERIE Team
JAMA. 2006; 295:1539-1548. [Abstract]
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Xueliang Du, Diane Edelstein, Silvana Obici, Ninon Higham, Ming-Hui Zou, and Michael Brownlee
J. Clin. Invest. 2006; 116:1071-1080. [Abstract]
Farnesoid X receptor is essential for normal glucose homeostasis
Ke Ma, Pradip K. Saha, Lawrence Chan, and David D. Moore
J. Clin. Invest. 2006; 116:1102-1109. [Abstract]
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Alessandro Pocai, Tony K.T. Lam, Silvana Obici, Roger Gutierrez-Juarez, Evan D. Muse, Arduino Arduini, and Luciano Rossetti
J. Clin. Invest. 2006; 116:1081-1091. [Abstract]
IRIG: Leptin resistance in "Nature Medicine"
10/03/2006 21:32 Filed in: 2006
Leptin resistance is believed to contribute to
obesity and insulin resistance. It was not clear why
leptin resistance happens in the body. In the current
issue of Nature Medicine, a study suggests that
c-reactive protein binds to leptin, and blocks leptin
interaction with its receptor. This was demonstrated
in transgenic mice overexpressing c-reactive protein.
This study provides a new mechanism for leptin
resistance. Attached is the PDF file of this paper.
Mitochondrial dysfunction is believed to contribute
to pathogenesis of insulin resistance and type 2
diabetes. A news report was published in Nature weeks
ago about the current status in this field. PDF file
of this report is also attached.
http://www.nature.com/nm/journal/v12/n4/abs/nm1372.html
http://www.nature.com/nature/journal/v440/n7084/full/440600a.html
By Jianping at PBRC
---------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
http://www.nature.com/nm/journal/v12/n4/abs/nm1372.html
http://www.nature.com/nature/journal/v440/n7084/full/440600a.html
By Jianping at PBRC
---------------------------------------------------
Jianping Ye, MD
Associate Professor
Pennington Biomedical Research Center
Louisiana State University
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu