Jan 2007
IRIG: Interesting papers in JCI and JBC
01/25/2007 00:14
Neuronal SH2B1 is essential for controlling energy
and glucose homeostasis
Decheng Ren, Yingjiang Zhou, David Morris, Minghua Li, Zhiqin Li, and Liangyou Rui
published 18 January 2007, 10.1172/JCI29417 [Abstract] [PDF]
MAP4K4 gene silencing in human skeletal muscle prevents TNF-a-induced insulin resistance
Karim Bouzakri and Juleen R. Zierath
published 16 January 2007, 10.1074/jbc.M608602200 [Abstract] [PDF]
Protein Kinase Cd Plays a Non-redundant Role in Insulin Secretion in Pancreatic B CellsToyoyoshi Uchida, Noseki Iwashita, Mica Ohara-Imaizumi, Takeshi Ogihara, Shintaro Nagai, Jong Bock Choi, Yoshifumi Tamura, Norihiro Tada, Ryuzo Kawamori, Keiichi I. Nakayama, Shinya Nagamatsu, and Hirotaka Watada J. Biol. Chem. 2007; 282:2707-2716. [Abstract] [Full Text] [PDF]
Glucose Stimulates Ca2+ Influx and Insulin Secretion in 2-Week-old B-Cells Lacking ATP-sensitive K+ ChannelsAndras Szollosi, Myriam Nenquin, Lydia Aguilar-Bryan, Joseph Bryan, and Jean-Claude Henquin J. Biol. Chem. 2007; 282:1747-1756. [Abstract] [Full Text] [PDF]
The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesiclesJun Shi and Konstantin V. Kandror published 12 January 2007, 10.1074/jbc.M608971200 [Abstract] [PDF]
Skp2 Controls Adipocyte Proliferation during the Development of ObesityTamon Sakai, Hiroshi Sakaue, Takehiro Nakamura, Mitsuru Okada, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Keiko Nakayama, Keiichi I. Nakayama, and Masato Kasuga J. Biol. Chem. 2007; 282:2038-2046. [Abstract] [Full Text] [PDF]
Calcineurin Regulates Skeletal Muscle Metabolism via Coordinated Changes in Gene ExpressionYun Chau Long, Stephan Glund, Pablo M. Garcia-Roves, and Juleen R. Zierath J. Biol. Chem. 2007; 282:1607-1614. [Abstract] [Full Text] [PDF]
Glucose Induces MafA Expression in Pancreatic Beta Cell Lines via the Hexosamine Biosynthetic PathwayNathan L. Vanderford, Sreenath S. Andrali, and Sabire Özcan J. Biol. Chem. 2007; 282:1577-1584. [Abstract] [Full Text] [PDF]
Regulation of S6 kinase 1 activation by phosphorylation at Ser411Zhibo Hou, Lisheng He, and Robert Z. Qi published 12 January 2007, 10.1074/jbc.M607836200 [Abstract] [PDF]
By Jianping at PBRC
—----------------------------------
Jianping Ye, MD Professor of Molecular Biology Pennington Biomedical Research Center Louisiana State University System 6400 Perkins Road Baton Rouge, LA 70808 Phone: (225) 763-3163 Fax: (225) 763-2525 E-mail: yej@pbrc.edu
Decheng Ren, Yingjiang Zhou, David Morris, Minghua Li, Zhiqin Li, and Liangyou Rui
published 18 January 2007, 10.1172/JCI29417 [Abstract] [PDF]
MAP4K4 gene silencing in human skeletal muscle prevents TNF-a-induced insulin resistance
Karim Bouzakri and Juleen R. Zierath
published 16 January 2007, 10.1074/jbc.M608602200 [Abstract] [PDF]
Protein Kinase Cd Plays a Non-redundant Role in Insulin Secretion in Pancreatic B CellsToyoyoshi Uchida, Noseki Iwashita, Mica Ohara-Imaizumi, Takeshi Ogihara, Shintaro Nagai, Jong Bock Choi, Yoshifumi Tamura, Norihiro Tada, Ryuzo Kawamori, Keiichi I. Nakayama, Shinya Nagamatsu, and Hirotaka Watada J. Biol. Chem. 2007; 282:2707-2716. [Abstract] [Full Text] [PDF]
Glucose Stimulates Ca2+ Influx and Insulin Secretion in 2-Week-old B-Cells Lacking ATP-sensitive K+ ChannelsAndras Szollosi, Myriam Nenquin, Lydia Aguilar-Bryan, Joseph Bryan, and Jean-Claude Henquin J. Biol. Chem. 2007; 282:1747-1756. [Abstract] [Full Text] [PDF]
The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesiclesJun Shi and Konstantin V. Kandror published 12 January 2007, 10.1074/jbc.M608971200 [Abstract] [PDF]
Skp2 Controls Adipocyte Proliferation during the Development of ObesityTamon Sakai, Hiroshi Sakaue, Takehiro Nakamura, Mitsuru Okada, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Keiko Nakayama, Keiichi I. Nakayama, and Masato Kasuga J. Biol. Chem. 2007; 282:2038-2046. [Abstract] [Full Text] [PDF]
Calcineurin Regulates Skeletal Muscle Metabolism via Coordinated Changes in Gene ExpressionYun Chau Long, Stephan Glund, Pablo M. Garcia-Roves, and Juleen R. Zierath J. Biol. Chem. 2007; 282:1607-1614. [Abstract] [Full Text] [PDF]
Glucose Induces MafA Expression in Pancreatic Beta Cell Lines via the Hexosamine Biosynthetic PathwayNathan L. Vanderford, Sreenath S. Andrali, and Sabire Özcan J. Biol. Chem. 2007; 282:1577-1584. [Abstract] [Full Text] [PDF]
Regulation of S6 kinase 1 activation by phosphorylation at Ser411Zhibo Hou, Lisheng He, and Robert Z. Qi published 12 January 2007, 10.1074/jbc.M607836200 [Abstract] [PDF]
By Jianping at PBRC
—----------------------------------
Jianping Ye, MD Professor of Molecular Biology Pennington Biomedical Research Center Louisiana State University System 6400 Perkins Road Baton Rouge, LA 70808 Phone: (225) 763-3163 Fax: (225) 763-2525 E-mail: yej@pbrc.edu
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IRIG: Controversy on obesity gene in Science
01/16/2007 22:01
It was reported in Science (Reports, 14 April
2006, p. 279) about an
association between the INSIG2
gene variant rs7566605 and obesity
in four sample populations, under a recessive model.
The controversy about the association is reported in
the current issue of Science. Data from a couple
of labs does not support the association. See
below.
In Science Magazine
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Christian Dina, David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, and Philippe Froguel (12 January 2007)
Science 315 (5809), 187b. [DOI: 10.1126/science.1129402]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Ruth J. F. Loos, Inês Barroso, Stephen O'Rahilly, and Nicholas J. Wareham (12 January 2007)
Science 315 (5809), 187c. [DOI: 10.1126/science.1130012]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Dieter Rosskopf, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K. Kroemer, and Henry Völzke (12 January 2007)
Science 315 (5809), 187d. [DOI: 10.1126/science.1130571]
| Abstract » | Full Text » | PDF »
REPORTS
A Common Genetic Variant Is Associated with Adult and Childhood Obesity
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (14 April 2006)
Science 312 (5771), 279. [DOI: 10.1126/science.1124779]
| Abstract » | Full Text » | PDF » | Supporting Online Material »
------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
In Science Magazine
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Christian Dina, David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, and Philippe Froguel (12 January 2007)
Science 315 (5809), 187b. [DOI: 10.1126/science.1129402]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Ruth J. F. Loos, Inês Barroso, Stephen O'Rahilly, and Nicholas J. Wareham (12 January 2007)
Science 315 (5809), 187c. [DOI: 10.1126/science.1130012]
| Abstract » | Full Text » | PDF »
TECHNICAL COMMENTS
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
Dieter Rosskopf, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K. Kroemer, and Henry Völzke (12 January 2007)
Science 315 (5809), 187d. [DOI: 10.1126/science.1130571]
| Abstract » | Full Text » | PDF »
REPORTS
A Common Genetic Variant Is Associated with Adult and Childhood Obesity
Alan Herbert, Norman P. Gerry, Matthew B. McQueen, Iris M. Heid, Arne Pfeufer, Thomas Illig, H.-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B. Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N. Hirschhorn, Nan M. Laird, Marc E. Lenburg, Christoph Lange, and Michael F. Christman (14 April 2006)
Science 312 (5771), 279. [DOI: 10.1126/science.1124779]
| Abstract » | Full Text » | PDF » | Supporting Online Material »
------------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763-3163
E-mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
IRIG: Controversy about Leptin CRP interaction
01/11/2007 04:18
In last year, Nature
Medicine reported that leptin interacts with CRP
(C-reactive peptide), and the interaction may account
for leptin resistance in obesity. This concept is
challenged by results from three independent groups
using different experiment systems. The
argument is published in the current issue of
Nature Medicine (see links below). This is also
recommended by Dr. Vishwa Dixit at PBRC.
Is leptin an important physiological regulator of CRP?
I Sadaf Farooqi and Stephen O'Rahilly
10.1038/nm0107-16
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAQ0Ey
Is leptin an important physiological regulator of CRP?
Winston L Hutchinson et al.
10.1038/nm0107-17
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAR0Ez
Is leptin an important physiological regulator of CRP?
Arieh Gertler, Leonora Niv-Spector and Shay Reicher
10.1038/nm0107-18
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAS0E1
Is leptin an important physiological regulator of CRP?
Allan Zhao
10.1038/nm0107-19
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAT0E2
by Jianping at PBRC
—--------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Is leptin an important physiological regulator of CRP?
I Sadaf Farooqi and Stephen O'Rahilly
10.1038/nm0107-16
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAQ0Ey
Is leptin an important physiological regulator of CRP?
Winston L Hutchinson et al.
10.1038/nm0107-17
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAR0Ez
Is leptin an important physiological regulator of CRP?
Arieh Gertler, Leonora Niv-Spector and Shay Reicher
10.1038/nm0107-18
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAS0E1
Is leptin an important physiological regulator of CRP?
Allan Zhao
10.1038/nm0107-19
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAT0E2
by Jianping at PBRC
—--------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Glucose is a ligand of nuclear receptor LXR in Nature
01/04/2007 07:20
LXR (liver X receptor) is a nuclear receptor with
alpha and beta isoforms. LXR function is well
established in the control of lipid metabolism in
liver. When it is activated by ligands such as
oxysterols and 6a-hydroxy
bile acids, it stimulates tryglicerides synthesis in
liver, and induces cholestreol efflux in macrophages.
This function is mediated through expression of
transcription factor SREBP, a target gene of
LXR. In Nature online
publication,
a study suggests that glucose is a physiological
ligand for LXR. Glucose is shown to activate the
transcriptional activity of LXR through direct
binding to LXR. LXR is claimed as a sensor for
glucose. The study provides a new mechanism by
which glucose controls lipid
synthesis. See attached PDF file.
by Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
by Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
IRIG: Interesting papers in Cell Metabolism and JCI
01/04/2007 07:17
A Central Thermogenic-like
Mechanism in Feeding Regulation: An Interplay
between Arcuate Nucleus T3 and UCP2
A. Coppola, Z.-W. Liu, Z.B. Andrews, E. Paradis, M.-C. Roy, J.M. Friedman, D. Ricquier, D. Richard, T.L. Horvath, X.-B. Gao, and S. Diano. Cell Metabolism, Vol 5, 21-33, January 2007
The Transcriptional Coactivator PGC-1ß Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle
Z. Arany, N. Lebrasseur, C. Morris, E. Smith, W. Yang, Y. Ma, S. Chin, and B.M. Spiegelman. Cell Metabolism, Vol 5, 21-33, January 2007
Glucokinase and IRS-2 are required for compensatory ß cell hyperplasia in response to high-fat diet–induced insulin resistance Yasuo Terauchi, Iseki Takamoto, Naoto Kubota, Junji Matsui, Ryo Suzuki, Kajuro Komeda, Akemi Hara, Yukiyasu Toyoda, Ichitomo Miwa, Shinichi Aizawa, Shuichi Tsutsumi, Yoshiharu Tsubamoto, Shinji Hashimoto, Kazuhiro Eto, Akinobu Nakamura, Mitsuhiko Noda, Kazuyuki Tobe, Hiroyuki Aburatani, Ryozo Nagai, and Takashi Kadowaki J. Clin. Invest. 2007; 117:246-257. [Abstract] [Full Text] [PDF]
A dominant role for glucose in ß cell compensation of insulin resistance Gordon C. Weir and Susan Bonner-Weir J. Clin. Invest. 2007; 117:81-83. [Abstract] [Full Text] [PDF]
Obesity induces a phenotypic switch in adipose tissue macrophage polarization Carey N. Lumeng, Jennifer L. Bodzin, and Alan R. Saltiel J. Clin. Invest. 2007; 117:175-184. [Abstract] [Full Text] [PDF]
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure Tanya Hansotia, Adriano Maida, Grace Flock, Yuichiro Yamada, Katsushi Tsukiyama, Yutaka Seino, and Daniel. J. Drucker J. Clin. Invest. 2007; 117:143-152. [Abstract] [Full Text] [PDF]
The first two papers in "Cell Metabolism" are recommended by Dr. Eric Revussin at the Pennington Biomedical Research Center.
-----------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail:yej@pbrc.edu
A. Coppola, Z.-W. Liu, Z.B. Andrews, E. Paradis, M.-C. Roy, J.M. Friedman, D. Ricquier, D. Richard, T.L. Horvath, X.-B. Gao, and S. Diano. Cell Metabolism, Vol 5, 21-33, January 2007
The Transcriptional Coactivator PGC-1ß Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle
Z. Arany, N. Lebrasseur, C. Morris, E. Smith, W. Yang, Y. Ma, S. Chin, and B.M. Spiegelman. Cell Metabolism, Vol 5, 21-33, January 2007
Glucokinase and IRS-2 are required for compensatory ß cell hyperplasia in response to high-fat diet–induced insulin resistance Yasuo Terauchi, Iseki Takamoto, Naoto Kubota, Junji Matsui, Ryo Suzuki, Kajuro Komeda, Akemi Hara, Yukiyasu Toyoda, Ichitomo Miwa, Shinichi Aizawa, Shuichi Tsutsumi, Yoshiharu Tsubamoto, Shinji Hashimoto, Kazuhiro Eto, Akinobu Nakamura, Mitsuhiko Noda, Kazuyuki Tobe, Hiroyuki Aburatani, Ryozo Nagai, and Takashi Kadowaki J. Clin. Invest. 2007; 117:246-257. [Abstract] [Full Text] [PDF]
A dominant role for glucose in ß cell compensation of insulin resistance Gordon C. Weir and Susan Bonner-Weir J. Clin. Invest. 2007; 117:81-83. [Abstract] [Full Text] [PDF]
Obesity induces a phenotypic switch in adipose tissue macrophage polarization Carey N. Lumeng, Jennifer L. Bodzin, and Alan R. Saltiel J. Clin. Invest. 2007; 117:175-184. [Abstract] [Full Text] [PDF]
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure Tanya Hansotia, Adriano Maida, Grace Flock, Yuichiro Yamada, Katsushi Tsukiyama, Yutaka Seino, and Daniel. J. Drucker J. Clin. Invest. 2007; 117:143-152. [Abstract] [Full Text] [PDF]
The first two papers in "Cell Metabolism" are recommended by Dr. Eric Revussin at the Pennington Biomedical Research Center.
-----------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail:yej@pbrc.edu
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