Aug 2008
IRIG: UCP2/grehlin and FGF21/insulin resistance
08/07/2008 13:58
Ghrelin, a 28‑aa gut
peptide, is a hormone secreted mainly
by stomach in response to starvation. It stimulates food intake through
induction of NPY/AgRP in the hypothalami. A new study at Nature online
suggests that UCP2 (uncoupling protein 2) is required for Ghrelin action
in the stimulation of food intake (See attached paper).
FGF21 (Fibroblast growth factor 21) is a PPARa target gene
in the liver. It's activities in the protection of insulin sensitivity
and anti‑obesity have drawn a lot of attention recently. Several studies
in animal models suggest that FGF21 has "good" metabolic activities.
FGF21‑transgenic animals are resistant to diet‑induced weight gain and
fat accumulation. Administration of FGF21 improved blood glucose,
insulin, and triglycerides (TG) in diabetic mice or monkeys. Its
expression is increased in starvation. FGF21 has been described as a
novel metabolic regulator and as a master hormonal switch for liver
ketogenesis and overall metabolic adaptation to fasting. Does FGF21 act
in human? In the current "Cell Metabolism", a new study shows that FGF21
expression is induced by prolonged fasting and PPARa activator in human.
Please find the details in attached paper.
By Jianping at PBRC/LSU
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763‑3163
E‑mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
by stomach in response to starvation. It stimulates food intake through
induction of NPY/AgRP in the hypothalami. A new study at Nature online
suggests that UCP2 (uncoupling protein 2) is required for Ghrelin action
in the stimulation of food intake (See attached paper).
FGF21 (Fibroblast growth factor 21) is a PPARa target gene
in the liver. It's activities in the protection of insulin sensitivity
and anti‑obesity have drawn a lot of attention recently. Several studies
in animal models suggest that FGF21 has "good" metabolic activities.
FGF21‑transgenic animals are resistant to diet‑induced weight gain and
fat accumulation. Administration of FGF21 improved blood glucose,
insulin, and triglycerides (TG) in diabetic mice or monkeys. Its
expression is increased in starvation. FGF21 has been described as a
novel metabolic regulator and as a master hormonal switch for liver
ketogenesis and overall metabolic adaptation to fasting. Does FGF21 act
in human? In the current "Cell Metabolism", a new study shows that FGF21
expression is induced by prolonged fasting and PPARa activator in human.
Please find the details in attached paper.
By Jianping at PBRC/LSU
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763‑3163
E‑mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
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