IRIG: Chronic inflammation in adipose tissue: How and Why?
12/15/2008 09:50
Chronic inflammation
occurs in adipose tissue in obesity. This
is observed in many excellent studies with an increase in inflammation
cytokines and macrophage infiltration. It has been a question, why does
the inflammation occurs, and how does it mean? For your reference, here
are some results from our studies. The inflammation is likely a result
of hypoxia response in adipose tissue (1), and inflammation may serves
as a signal to stimulate angiogenesis in adipose tissue (2). The hypoxia
response may promote macrophage infiltration through induction of
chemokines (MIF) (1) as well as adipocyte death (3). The hypoxia may
contribute to systemic insulin resistance by increasing FFA and
decreasing adiponectin in circulation since it inhibits storage (TAG)
and secretion functions in adipocytes (1; 3). Adipose tissue hypoxia may
explain many other malfunction in adipose tissue and insulin resistance
in obstructive sleep apnea in obesity (4). Possible cause of the adipose
tissue hypoxia is discussed in a review (4). To keep the post short, I
am sorry that related studies by other labs are not cited here. They are
in the review article (Attached PDF file).
1. Ye J, Gao Z, Yin J, He H: Hypoxia is a potential risk factor for
chronic inflammation and adiponectin reduction in adipose tissue of
ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab
293:E1118‑E1128, 2007
2. Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J: Macrophage Infiltration
into Adipose Tissue May Promote Angiogenesis for Adipose Tissue
Remodeling in Obesity. Am J Physiol Endocrinol Metab 295:E313‑E322, 2008
3. Yin J, Gao Z, He Q, Ye J: Role of hypoxia in obesity‑induced
disorders of glucose and lipid metabolism in adipose tissue. Am J
Physiol Endocrinol Metab doi:10.1152/ajpendo.90760.2008
4. Ye J: Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin
Resistance. Int J Obes DOI: Dec. 9th 2007, 2008
By Jianping at PBRC
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763‑3163
E‑mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
IRIR stands for "Insulin Resistance Interest Group", an electronic and
non‑profitable academic activity for promotion of basic research in
metabolic syndrome. The activity was started by me in 2003 at the
Pennington Biomedical Research Center. If you prefer to stop receiving
this type of e‑mail in the future, please let me know. I will be happy
to make a change in the e‑mail list. The previous posts can be found at:
http://c-ada.org/journalclub/journalclub.html. Your comments on the
post are welcome.
is observed in many excellent studies with an increase in inflammation
cytokines and macrophage infiltration. It has been a question, why does
the inflammation occurs, and how does it mean? For your reference, here
are some results from our studies. The inflammation is likely a result
of hypoxia response in adipose tissue (1), and inflammation may serves
as a signal to stimulate angiogenesis in adipose tissue (2). The hypoxia
response may promote macrophage infiltration through induction of
chemokines (MIF) (1) as well as adipocyte death (3). The hypoxia may
contribute to systemic insulin resistance by increasing FFA and
decreasing adiponectin in circulation since it inhibits storage (TAG)
and secretion functions in adipocytes (1; 3). Adipose tissue hypoxia may
explain many other malfunction in adipose tissue and insulin resistance
in obstructive sleep apnea in obesity (4). Possible cause of the adipose
tissue hypoxia is discussed in a review (4). To keep the post short, I
am sorry that related studies by other labs are not cited here. They are
in the review article (Attached PDF file).
1. Ye J, Gao Z, Yin J, He H: Hypoxia is a potential risk factor for
chronic inflammation and adiponectin reduction in adipose tissue of
ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab
293:E1118‑E1128, 2007
2. Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J: Macrophage Infiltration
into Adipose Tissue May Promote Angiogenesis for Adipose Tissue
Remodeling in Obesity. Am J Physiol Endocrinol Metab 295:E313‑E322, 2008
3. Yin J, Gao Z, He Q, Ye J: Role of hypoxia in obesity‑induced
disorders of glucose and lipid metabolism in adipose tissue. Am J
Physiol Endocrinol Metab doi:10.1152/ajpendo.90760.2008
4. Ye J: Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin
Resistance. Int J Obes DOI: Dec. 9th 2007, 2008
By Jianping at PBRC
‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑‑
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225)763‑3163
E‑mail: yej@pbrc.edu
Webpage: http://labs.pbrc.edu/generegulation/index.htm
IRIR stands for "Insulin Resistance Interest Group", an electronic and
non‑profitable academic activity for promotion of basic research in
metabolic syndrome. The activity was started by me in 2003 at the
Pennington Biomedical Research Center. If you prefer to stop receiving
this type of e‑mail in the future, please let me know. I will be happy
to make a change in the e‑mail list. The previous posts can be found at:
http://c-ada.org/journalclub/journalclub.html. Your comments on the
post are welcome.
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