IRIG: Glucose is a ligand of nuclear receptor LXR in Nature
01/04/2007 07:20
LXR (liver X receptor) is a nuclear receptor with
alpha and beta isoforms. LXR function is well
established in the control of lipid metabolism in
liver. When it is activated by ligands such as
oxysterols and 6a-hydroxy
bile acids, it stimulates tryglicerides synthesis in
liver, and induces cholestreol efflux in macrophages.
This function is mediated through expression of
transcription factor SREBP, a target gene of
LXR. In Nature online
publication,
a study suggests that glucose is a physiological
ligand for LXR. Glucose is shown to activate the
transcriptional activity of LXR through direct
binding to LXR. LXR is claimed as a sensor for
glucose. The study provides a new mechanism by
which glucose controls lipid
synthesis. See attached PDF file.
by Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
by Jianping at PBRC
—-----------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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