IRIG: Macrophage as TZD target for insulin sensitization in Natureand JCI
07/11/2007 02:16
TZD is a powerful
medicine for improvement of insulin sensitivity in
both human and animals. Adipocytes are
generally believed as the primary target of TZD,
which activates the nuclear receptor
PPARg. PPARg expression is highest in
adipocytes and adipocyte differentiation is
induced by TZD. However, this concept is challenged
by new studies published in Nature and JCI in
June. Both studies consistently suggest that PPARg in
macrophages is required for maintenance of
insulin sensitivity and energy balance. When
PPARg is specifically knocked out in macrophages,
mice developed metabolic syndrom and lost response to
TZD. See details in attached PDF
files.
Akt is a serine kinase in insulin signaling pathway. The up- and down-stream molecules of Akt are actively studied in several fields, including endocrinology, immunology and cancer biology. The reason is that Akt is also involved in signaling transduction of other growth factors. Attached include a review for Akt in this issue of Cell.
By Jianping at PBRC/LSU
----------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Akt is a serine kinase in insulin signaling pathway. The up- and down-stream molecules of Akt are actively studied in several fields, including endocrinology, immunology and cancer biology. The reason is that Akt is also involved in signaling transduction of other growth factors. Attached include a review for Akt in this issue of Cell.
By Jianping at PBRC/LSU
----------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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