IRIG: Controversy about Leptin CRP interaction

01/11/2007 04:18
In last year, Nature Medicine reported that leptin interacts with CRP (C-reactive peptide), and the interaction may account for leptin resistance in obesity. This concept is challenged by results from three independent groups using different experiment systems. The argument is published in the current issue of Nature Medicine (see links below). This is also recommended by Dr. Vishwa Dixit at PBRC.  
 
Is leptin an important physiological regulator of CRP?
I Sadaf Farooqi and Stephen O'Rahilly
10.1038/nm0107-16
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAQ0Ey
 
Is leptin an important physiological regulator of CRP?
Winston L Hutchinson et al.
10.1038/nm0107-17
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAR0Ez
 
Is leptin an important physiological regulator of CRP?
Arieh Gertler, Leonora Niv-Spector and Shay Reicher
10.1038/nm0107-18
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAS0E1
 
Is leptin an important physiological regulator of CRP?
Allan Zhao
10.1038/nm0107-19
http://ealerts.nature.com/cgi-bin24/DM/y/ebtw0SohGc0HjT0BJAT0E2
 
by Jianping at PBRC

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Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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