IRIG: Longevity and Immunity in "Nature"
11/02/2006 20:09
SIRT1 is a longevity protein whose activity is
positively associated with longevity. The chemical
nature of SIRT1 is histone deacetylase. In yeast,
SIRT1 is called Sir2. The function of SIRT1/Sir2 is
increased by caloric restriction. In the
nucleus, SIRT1 regulates gene transcription
through modification of chromatin
structure. SIRT1 in known to regulate
the transcriptional activities of
several nuclear factors including p53, NF-kB,
PPARg, and PGC-1. It was speculated that a
chemical activator of SIRT1 should be able to extend
life span in mammalians. Resveratrol, an extract from
botanicals especially skin of grapes, is one of
the chemical activators of SIRT1. Resveratrol has
been well known for its anti-cancer activities.
In Nature online, it is reported that
resveratrol is able to extend the life span of obese
mice, and the mechanism is associated with insulin
sensitization by resverarol.
See attached PDF
file.
The endocrine function of adipose tissues is well known in obesity field. Leptin and adiponectin are two unique cytokines in the adipose tissue. Many other adipokines (such as TNF-a, IL-6, and MCP1) are also produced by immune cells. A possible interaction between adipose tissue and immune system has been in speculation for some times. However, there is not many good review articles to address the interaction in detail. In the current "Nature Reviews Immunology", such a review is available now. See attached PDF file.
By Jianping at PBRC
—---------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
The endocrine function of adipose tissues is well known in obesity field. Leptin and adiponectin are two unique cytokines in the adipose tissue. Many other adipokines (such as TNF-a, IL-6, and MCP1) are also produced by immune cells. A possible interaction between adipose tissue and immune system has been in speculation for some times. However, there is not many good review articles to address the interaction in detail. In the current "Nature Reviews Immunology", such a review is available now. See attached PDF file.
By Jianping at PBRC
—---------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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