IRIG: Papers in Nature about PGC-1 and Food intake
10/18/2006 21:18 Filed in: 2006
PGC-1 (PPARg coactivator 1) was identified as
a transcriptional coactivator for nuclear
receptor PPARg. Now, PGC-1 is known to interact with
many transcription factors in the regulation of gene
expression in addition to PPARg. The biological
activities of PGC-1 are well-established in the
promotion of hepatic gluconeogenesis and
mitochondrial biosynthesis. In the regulation of
gluconeogenesis in the liver, PGC-1 has
been shown to promote transcription of
the rate-limiting enzyme (G6Pase and
PEPCK) through an interaction
with transcription factors including HNF4, FOXO1
and CREB. In a recent issue of Nature, it
is reported that PGC-1 does not directly
interact with FOXO1 in G6Pase gene promoter, and is
not required for the FOXO1 function. The PGC-1/HNF4
interaction is confirmed for their function in
G6Pase expression. Attached is the PDF
file.
Regulation of food intake is a focus in obesity research with an expectation that the research will lead to identification of a target for drug intervention of food intake, which will be useful in prevention and treatment of obesity. However, the current understanding of the mechanism of food intake has not been able to provide an effective drug target for such a purpose. As a result, the research in this field has drawn a great deal of attention. This is reflected by the increasing number of review articles in the high profile journals in recent years. In Nature, a review about food intake is published recently (see attached PDF file). This paper is recommended by Dr. Roy Martin at Pennington.
By Jianping at PBRC
—---------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
Regulation of food intake is a focus in obesity research with an expectation that the research will lead to identification of a target for drug intervention of food intake, which will be useful in prevention and treatment of obesity. However, the current understanding of the mechanism of food intake has not been able to provide an effective drug target for such a purpose. As a result, the research in this field has drawn a great deal of attention. This is reflected by the increasing number of review articles in the high profile journals in recent years. In Nature, a review about food intake is published recently (see attached PDF file). This paper is recommended by Dr. Roy Martin at Pennington.
By Jianping at PBRC
—---------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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