IRIG: Insulin, PGC-1, GSK-3 in "Nature" and "Cell"
10/30/2006 07:16 Filed in: 2006
In the current "Nature Reviews: Molecular Cell
Biology", there is a nice review article about
signaling pathway of insulin. It introduces current
understanding of the pathway and also summarizes
major events in the history on study of
the pathway.
Attached is the PDF file
(provided by Feng Liu at UTHSCS).
In the current "Cell", a study demonstrates that PGC-1a is an important nuclear protein in the inhibition of reactive oxygen species (ROS). In the absence of PGC-1a, ROS production is increased from the respiratory chain reaction in the mitochondria. The ROS leads to degeration of neuron in cell culture and in PGC-1a KO mice. See attached PFD file.
In the current "Molecular Cell", a study suggests that mTOR/S6K is able to regulate GSK-3 activity through Akt. See attached PDF file.
In the current JCI, a study supports that free fatty acids induce inflammation in adipocytes and macrophages through activation of the Toll like receptor 4 (TLR4). In the TLR4 knockout female mice, inflammation was reduced and insulin sensitivity was preserved on high fat diet although the body weight was even higher. See attached PDF file.
By Jianping at PBRC
—-------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
In the current "Cell", a study demonstrates that PGC-1a is an important nuclear protein in the inhibition of reactive oxygen species (ROS). In the absence of PGC-1a, ROS production is increased from the respiratory chain reaction in the mitochondria. The ROS leads to degeration of neuron in cell culture and in PGC-1a KO mice. See attached PFD file.
In the current "Molecular Cell", a study suggests that mTOR/S6K is able to regulate GSK-3 activity through Akt. See attached PDF file.
In the current JCI, a study supports that free fatty acids induce inflammation in adipocytes and macrophages through activation of the Toll like receptor 4 (TLR4). In the TLR4 knockout female mice, inflammation was reduced and insulin sensitivity was preserved on high fat diet although the body weight was even higher. See attached PDF file.
By Jianping at PBRC
—-------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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