IRIG: Regulation of fat inflammation by STAMP (Cell paper)

05/09/2007 21:28
 Inflammation contributes to insulin resistance in obesity. However, it is not clear what molecular pathway is involved in initiation of the chronic inflammation (such as TNFa, IL-6 expression and macrophage infiltration) in adipose tissue under obesity. Although FFA and ER stress have been shown to contribute to the inflammatory response, the whole story seems far from completed. The search for new molecule or mechanism is undergoing in adipose tissue. In this respect, a new study published in the current issue of "Cell" demonstrates that a transmembrane protein "STAMP2" is a new molecule for the story. STAMP2 belongs to the STAMP or STEAP family of six transmembrane domain proteins. Members of this family are metalloreductases that are important for the cellular import of iron and copper. Loss of STAMP2 in mice leads to increased inflammatory response in adipose tissue. See full text of the paper in attached PDF file.
 
By Jianping at PBRC

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Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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