IRIG: New diabetes genes and models for GKS-3b in Nature

02/16/2007 01:03
There are two interesting papers published online in Nature. The first one is about identification of new genes for type 2 diabetes through genome-wide analysis of gene polymorphism. A couple of beta-cell specific genes were found to associate with risk of type 2 diabetes. The second study describes a new model for analysis of GSK-3b function in transgenic mice. GSK-3b is quickly degraded after tagged with a short amino acid sequence by the name of FRB (FKBP/rapamycin binding). The degradation leads to inactivation of GSK-3b in the transgenic mice. Rapamycin is able to block the degradation in vivo through specific binding to the tag domain in the fusion protein of GSK-3b. Following are the links to these two papers.        
 
ADVANCE ONLINE PUBLICATION
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11 February 2007
Article
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek et al.
doi:10.1038/nature05616
http://ealerts.nature.com/cgi-bin24/DM/y/ecWf0SohGc0HjB0BL4G0Ea
See also: News and Views by Freimer & Sabatti
http://ealerts.nature.com/cgi-bin24/DM/y/ecWf0SohGc0HjB0BL4H0Eb
 
Letters
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice
Karen J. Liu et al.
doi:10.1038/nature05557
http://ealerts.nature.com/cgi-bin24/DM/y/ecWf0SohGc0HjB0BL4I0Ec
 
by Jianping at PBRC

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Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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