IRIG: Obesity in "Cell" and "Science"
05/20/2007 21:18
In the current issue of
Cell, a
very nice review article summarizes recent
advance in hormone control of food intake,
a central topic in the study of obesity.
Hormones or peptides produced by fat cells, the
gastrointestinal tract, and the pancreas are
discussed in the regulation of appetite. The
molecular pathway is proposed for each
hormones.
In the current issue of Science, a new gene by the name of FTO (fat mass and obesity associated gene) is reported as a genetic factor predisposing to obesity. This gene is identified through a genowise screening of human genes. Mutation of this gene is associated with an increase in body weight or BMI.
In obesity, hyperinsulinemia and insulin resistance stays together. Their relationship represents a question of chicken and egg. Although most people believe that insulin resistance happens before hyperinsulinemia in obesity, the concept remains to be tested. With an interest into this question, I reviewed literature and wrote an article to support hyperinsulinemia for insulin resistance. I have received many requests for it through e-mail. Here, I wish to share it with you. Comments are welcome.
Attached are the PDF files of three papers mentioned above.
By Jianping at PBRC
—-----------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
In the current issue of Science, a new gene by the name of FTO (fat mass and obesity associated gene) is reported as a genetic factor predisposing to obesity. This gene is identified through a genowise screening of human genes. Mutation of this gene is associated with an increase in body weight or BMI.
In obesity, hyperinsulinemia and insulin resistance stays together. Their relationship represents a question of chicken and egg. Although most people believe that insulin resistance happens before hyperinsulinemia in obesity, the concept remains to be tested. With an interest into this question, I reviewed literature and wrote an article to support hyperinsulinemia for insulin resistance. I have received many requests for it through e-mail. Here, I wish to share it with you. Comments are welcome.
Attached are the PDF files of three papers mentioned above.
By Jianping at PBRC
—-----------------------------------------------------
Jianping Ye, MD
Professor of Molecular Biology
Pennington Biomedical Research Center
Louisiana State University System
6400 Perkins Road
Baton Rouge, LA 70808
Phone: (225) 763-3163
Fax: (225) 763-2525
E-mail: yej@pbrc.edu
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